Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology
To date, pancreatic cancer is still one of the most lethal cancers in the world, mainly due to the lack of early diagnosis and personalized treatment strategies. In this context, the possibility and the opportunity of identifying genetic and molecular biomarkers are crucial to improve the feasibilit...
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8841 |
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| author | Chiara Bazzichetto Claudio Luchini Fabiana Conciatori Vanja Vaccaro Ilaria Di Cello Paola Mattiolo Italia Falcone Gianluigi Ferretti Aldo Scarpa Francesco Cognetti Michele Milella |
| author_facet | Chiara Bazzichetto Claudio Luchini Fabiana Conciatori Vanja Vaccaro Ilaria Di Cello Paola Mattiolo Italia Falcone Gianluigi Ferretti Aldo Scarpa Francesco Cognetti Michele Milella |
| author_sort | Chiara Bazzichetto |
| collection | DOAJ |
| description | To date, pancreatic cancer is still one of the most lethal cancers in the world, mainly due to the lack of early diagnosis and personalized treatment strategies. In this context, the possibility and the opportunity of identifying genetic and molecular biomarkers are crucial to improve the feasibility of precision medicine. In 2019, the World Health Organization classified pancreatic ductal adenocarcinoma cancer (the most common pancreatic tumor type) into eight variants, according to specific histomorphological features. They are: colloid carcinoma, medullary carcinoma, adenosquamous carcinoma, undifferentiated carcinoma, including also rhabdoid carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, hepatoid carcinoma, and signet-ring/poorly cohesive cells carcinoma. Interestingly, despite the very low incidence of these variants, innovative high throughput genomic/transcriptomic techniques allowed the investigation of both somatic and germline mutations in each specific variant, paving the way for their possible classification according also to specific alterations, along with the canonical mutations of pancreatic cancer (<i>KRAS</i>, <i>TP53</i>, <i>CDKN2A</i>, <i>SMAD4</i>). In this review, we aim to report the current evidence about genetic/molecular profiles of pancreatic cancer variants, highlighting their role in therapeutic and clinical impact. |
| first_indexed | 2024-03-10T14:39:08Z |
| format | Article |
| id | doaj.art-9fbe8f8559894d1896ce92e9651eca8e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:39:08Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9fbe8f8559894d1896ce92e9651eca8e2023-11-20T21:55:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122884110.3390/ijms21228841Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision OncologyChiara Bazzichetto0Claudio Luchini1Fabiana Conciatori2Vanja Vaccaro3Ilaria Di Cello4Paola Mattiolo5Italia Falcone6Gianluigi Ferretti7Aldo Scarpa8Francesco Cognetti9Michele Milella10Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, ItalyMedical Oncology 1, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyMedical Oncology 1, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, ItalyMedical Oncology 1, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyMedical Oncology 1, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment ARC-Net Research Centre, University and Hospital Trust of Verona, 37126 Verona, ItalyMedical Oncology 1, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDivision of Oncology, University of Verona, 37126 Verona, ItalyTo date, pancreatic cancer is still one of the most lethal cancers in the world, mainly due to the lack of early diagnosis and personalized treatment strategies. In this context, the possibility and the opportunity of identifying genetic and molecular biomarkers are crucial to improve the feasibility of precision medicine. In 2019, the World Health Organization classified pancreatic ductal adenocarcinoma cancer (the most common pancreatic tumor type) into eight variants, according to specific histomorphological features. They are: colloid carcinoma, medullary carcinoma, adenosquamous carcinoma, undifferentiated carcinoma, including also rhabdoid carcinoma, undifferentiated carcinoma with osteoclast-like giant cells, hepatoid carcinoma, and signet-ring/poorly cohesive cells carcinoma. Interestingly, despite the very low incidence of these variants, innovative high throughput genomic/transcriptomic techniques allowed the investigation of both somatic and germline mutations in each specific variant, paving the way for their possible classification according also to specific alterations, along with the canonical mutations of pancreatic cancer (<i>KRAS</i>, <i>TP53</i>, <i>CDKN2A</i>, <i>SMAD4</i>). In this review, we aim to report the current evidence about genetic/molecular profiles of pancreatic cancer variants, highlighting their role in therapeutic and clinical impact.https://www.mdpi.com/1422-0067/21/22/8841pancreatic cancervariantshistologygenetic statusmolecular alterationprecision medicine |
| spellingShingle | Chiara Bazzichetto Claudio Luchini Fabiana Conciatori Vanja Vaccaro Ilaria Di Cello Paola Mattiolo Italia Falcone Gianluigi Ferretti Aldo Scarpa Francesco Cognetti Michele Milella Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology International Journal of Molecular Sciences pancreatic cancer variants histology genetic status molecular alteration precision medicine |
| title | Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology |
| title_full | Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology |
| title_fullStr | Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology |
| title_full_unstemmed | Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology |
| title_short | Morphologic and Molecular Landscape of Pancreatic Cancer Variants as the Basis of New Therapeutic Strategies for Precision Oncology |
| title_sort | morphologic and molecular landscape of pancreatic cancer variants as the basis of new therapeutic strategies for precision oncology |
| topic | pancreatic cancer variants histology genetic status molecular alteration precision medicine |
| url | https://www.mdpi.com/1422-0067/21/22/8841 |
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