The N-Terminal Domain of Bfa1 Coordinates Mitotic Exit Independent of GAP Activity in <i>Saccharomyces cerevisiae</i>

The N-Terminal Domain of Bfa1 Coordinates Mitotic Exit Independent of GAP Activity in <i>Saccharomyces cerevisiae</i>

The spindle position checkpoint (SPOC) of budding yeast delays mitotic exit in response to misaligned spindles to ensure cell survival and the maintenance of genomic stability. The GTPase-activating protein (GAP) complex Bfa1–Bub2, a key SPOC component, inhibits the GTPase Tem1 to induce mitotic arr...

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Bibliographic Details
Main Authors: Yan Li, Kiwon Song
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
spindle misorientation
SPOC
Bfa1
microtubule hyper-elongation
spindle pole body
mitotic exit
Online Access:https://www.mdpi.com/2073-4409/11/14/2179

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