Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery
There are numerous pyrazine and phenazine compounds that demonstrate biological activities relevant to the treatment of disease. In this review, we discuss pyrazine and phenazine agents that have shown potential therapeutic value, including several clinically used agents. In addition, we cover some...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/3/1112 |
| _version_ | 1827659665329094656 |
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| author | Robert W. Huigens Beau R. Brummel Srinivasarao Tenneti Aaron T. Garrison Tao Xiao |
| author_facet | Robert W. Huigens Beau R. Brummel Srinivasarao Tenneti Aaron T. Garrison Tao Xiao |
| author_sort | Robert W. Huigens |
| collection | DOAJ |
| description | There are numerous pyrazine and phenazine compounds that demonstrate biological activities relevant to the treatment of disease. In this review, we discuss pyrazine and phenazine agents that have shown potential therapeutic value, including several clinically used agents. In addition, we cover some basic science related to pyrazine and phenazine heterocycles, which possess interesting reactivity profiles that have been on display in numerous cases of innovative total synthesis approaches, synthetic methodologies, drug discovery efforts, and medicinal chemistry programs. The majority of this review is focused on presenting instructive total synthesis and medicinal chemistry efforts of select pyrazine and phenazine compounds, and we believe these incredible heterocycles offer promise in medicine. |
| first_indexed | 2024-03-09T23:26:36Z |
| format | Article |
| id | doaj.art-9fc09ad1147d40258c9185047ce5d0ac |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:26:36Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9fc09ad1147d40258c9185047ce5d0ac2023-11-23T17:17:46ZengMDPI AGMolecules1420-30492022-02-01273111210.3390/molecules27031112Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug DiscoveryRobert W. Huigens0Beau R. Brummel1Srinivasarao Tenneti2Aaron T. Garrison3Tao Xiao4Center for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USACenter for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USACenter for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USACenter for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USACenter for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USAThere are numerous pyrazine and phenazine compounds that demonstrate biological activities relevant to the treatment of disease. In this review, we discuss pyrazine and phenazine agents that have shown potential therapeutic value, including several clinically used agents. In addition, we cover some basic science related to pyrazine and phenazine heterocycles, which possess interesting reactivity profiles that have been on display in numerous cases of innovative total synthesis approaches, synthetic methodologies, drug discovery efforts, and medicinal chemistry programs. The majority of this review is focused on presenting instructive total synthesis and medicinal chemistry efforts of select pyrazine and phenazine compounds, and we believe these incredible heterocycles offer promise in medicine.https://www.mdpi.com/1420-3049/27/3/1112pyrazinephenazineheterocyclic chemistrytotal synthesismedicinal chemistry |
| spellingShingle | Robert W. Huigens Beau R. Brummel Srinivasarao Tenneti Aaron T. Garrison Tao Xiao Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery Molecules pyrazine phenazine heterocyclic chemistry total synthesis medicinal chemistry |
| title | Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery |
| title_full | Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery |
| title_fullStr | Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery |
| title_full_unstemmed | Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery |
| title_short | Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery |
| title_sort | pyrazine and phenazine heterocycles platforms for total synthesis and drug discovery |
| topic | pyrazine phenazine heterocyclic chemistry total synthesis medicinal chemistry |
| url | https://www.mdpi.com/1420-3049/27/3/1112 |
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