Probing delivery of a lipid nanoparticle encapsulated self-amplifying mRNA vaccine using coherent Raman microscopy and multiphoton imaging

Probing delivery of a lipid nanoparticle encapsulated self-amplifying mRNA vaccine using coherent Raman microscopy and multiphoton imaging

Abstract The COVID-19 pandemic triggered the resurgence of synthetic RNA vaccine platforms allowing rapid, scalable, low-cost manufacturing, and safe administration of therapeutic vaccines. Self-amplifying mRNA (SAM), which self-replicates upon delivery into the cellular cytoplasm, leads to a strong...

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Bibliographic Details
Main Authors: Kajari Bera, Renán A. Rojas-Gómez, Prabuddha Mukherjee, Corey E. Snyder, Edita Aksamitiene, Aneesh Alex, Darold R. Spillman, Marina Marjanovic, Ahmed Shabana, Russell Johnson, Steve R. Hood, Stephen A. Boppart
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Self-amplifying mRNA
CARS
FLIM
Lipid nanoparticles
Online Access:https://doi.org/10.1038/s41598-024-54697-3

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