Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty
Objective:Longitudinal data regarding random luteinizing hormone (LH) concentrations in patients with idiopathic central precocious puberty (ICPP) during treatment are limited. Therefore, we sought to evaluate random LH and estradiol concentrations during monthly leuprolide injection and their assoc...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2019-09-01
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| Series: | JCRPE |
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http://www.jcrpe.org/archives/archive-detail/article-preview/elevated-random-luteinizing-hormone-is-an-unreliab/21134
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| _version_ | 1797924156177645568 |
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| author | Pattara Wiromrat Ouyporn Panamonta |
| author_facet | Pattara Wiromrat Ouyporn Panamonta |
| author_sort | Pattara Wiromrat |
| collection | DOAJ |
| description | Objective:Longitudinal data regarding random luteinizing hormone (LH) concentrations in patients with idiopathic central precocious puberty (ICPP) during treatment are limited. Therefore, we sought to evaluate random LH and estradiol concentrations during monthly leuprolide injection and their associations with pubertal progression and final adult height (FAH) in girls with ICPP.Methods:Medical records of 27 girls with ICPP who had attained FAH were reviewed. Patients’ height, weight, Tanner stage, growth rate (GR), bone age, random LH measured by both immunoradiometric and immunochemiluminescent methods, follicular-stimulating hormone (FSH) and estradiol levels were monitored until FAH.Results:Treatment was started at a mean (±standard deviation) age of 8.1±0.6 years with mean duration of 3.9±0.2 years. At six months of follow-up, random LH (p=0.048), FSH (p<0.001) and estradiol (p=0.023) concentrations were decreased compared with baseline. Thereafter, random LHs were well suppressed. GRs gradually decreased to prepubertal norm by month 12. Seventeen patients (63%) exhibited pubertal LH concentrations at least once during treatment visits. Furthermore, 43 of a total 116 (37%) LH measurements were found elevated. However, those patients with elevated random LH did not show signs of pubertal progression. After treatment, mean FAH was greater than predicted adult height (p<0.0001) and target height (p=0.03). At no time points of treatment did random LH, FSH and estradiol correlate with GRs or FAH.Conclusion:Elevated random LH is commonly found in ICPP girls during monthly leuprolide treatment. However, these elevations were not associated with clinical progression of puberty or decreased FAH, suggesting that it is not a reliable method for CPP monitoring. |
| first_indexed | 2024-04-10T14:57:52Z |
| format | Article |
| id | doaj.art-9fc1f70a8fbf46b7803944dab70a52e5 |
| institution | Directory Open Access Journal |
| issn | 1308-5727 1308-5735 |
| language | English |
| last_indexed | 2024-04-10T14:57:52Z |
| publishDate | 2019-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj.art-9fc1f70a8fbf46b7803944dab70a52e52023-02-15T16:07:17ZengGalenos YayincilikJCRPE1308-57271308-57352019-09-0111322723310.4274/jcrpe.galenos.2018.2018.021313049054Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious PubertyPattara Wiromrat0Ouyporn Panamonta1 Khon Kaen University Faculty of Medicine, Department of Pediatrics, Division of Endocrinology, Khon Kaen, Thailand Khon Kaen University Faculty of Medicine, Department of Pediatrics, Division of Endocrinology, Khon Kaen, Thailand Objective:Longitudinal data regarding random luteinizing hormone (LH) concentrations in patients with idiopathic central precocious puberty (ICPP) during treatment are limited. Therefore, we sought to evaluate random LH and estradiol concentrations during monthly leuprolide injection and their associations with pubertal progression and final adult height (FAH) in girls with ICPP.Methods:Medical records of 27 girls with ICPP who had attained FAH were reviewed. Patients’ height, weight, Tanner stage, growth rate (GR), bone age, random LH measured by both immunoradiometric and immunochemiluminescent methods, follicular-stimulating hormone (FSH) and estradiol levels were monitored until FAH.Results:Treatment was started at a mean (±standard deviation) age of 8.1±0.6 years with mean duration of 3.9±0.2 years. At six months of follow-up, random LH (p=0.048), FSH (p<0.001) and estradiol (p=0.023) concentrations were decreased compared with baseline. Thereafter, random LHs were well suppressed. GRs gradually decreased to prepubertal norm by month 12. Seventeen patients (63%) exhibited pubertal LH concentrations at least once during treatment visits. Furthermore, 43 of a total 116 (37%) LH measurements were found elevated. However, those patients with elevated random LH did not show signs of pubertal progression. After treatment, mean FAH was greater than predicted adult height (p<0.0001) and target height (p=0.03). At no time points of treatment did random LH, FSH and estradiol correlate with GRs or FAH.Conclusion:Elevated random LH is commonly found in ICPP girls during monthly leuprolide treatment. However, these elevations were not associated with clinical progression of puberty or decreased FAH, suggesting that it is not a reliable method for CPP monitoring. http://www.jcrpe.org/archives/archive-detail/article-preview/elevated-random-luteinizing-hormone-is-an-unreliab/21134 Central precocious pubertyfinal adult heightleuprolide acetatemonitoringpubertal progressionrandom luteinizing hormone |
| spellingShingle | Pattara Wiromrat Ouyporn Panamonta Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty JCRPE Central precocious puberty final adult height leuprolide acetate monitoring pubertal progression random luteinizing hormone |
| title | Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty |
| title_full | Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty |
| title_fullStr | Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty |
| title_full_unstemmed | Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty |
| title_short | Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty |
| title_sort | elevated random luteinizing hormone is an unreliable indicator for pubertal suppression in girls treated with monthly leuprolide for idiopathic central precocious puberty |
| topic | Central precocious puberty final adult height leuprolide acetate monitoring pubertal progression random luteinizing hormone |
| url |
http://www.jcrpe.org/archives/archive-detail/article-preview/elevated-random-luteinizing-hormone-is-an-unreliab/21134
|
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