Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children
Periadolescence is a neurodevelopmental period characterized by structural and functional brain changes that are associated with cognitive maturation. The development of the functional connectivity of the hippocampus contributes to cognitive maturation, especially memory processes. Notably, hippocam...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/11/1558 |
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| author | Abi Heller-Wight Connor Phipps Jennifer Sexton Meghan Ramirez David E. Warren |
| author_facet | Abi Heller-Wight Connor Phipps Jennifer Sexton Meghan Ramirez David E. Warren |
| author_sort | Abi Heller-Wight |
| collection | DOAJ |
| description | Periadolescence is a neurodevelopmental period characterized by structural and functional brain changes that are associated with cognitive maturation. The development of the functional connectivity of the hippocampus contributes to cognitive maturation, especially memory processes. Notably, hippocampal development is influenced by lifestyle factors, including physical activity. Physical activity has been associated with individual variability in hippocampal functional connectivity. However, this relationship has not been characterized in a developmental cohort. In this study, we aimed to fill this gap by investigating the relationship between physical activity and the functional connectivity of the hippocampus in a cohort of periadolescents aged 8–13 years (N = 117). The participants completed a physical activity questionnaire, reporting the number of days per week they performed 60 min of physical activity; then, they completed a resting-state functional MRI scan. We observed that greater physical activity was significantly associated with differences in hippocampal functional connectivity in frontal and temporal regions. Greater physical activity was associated with decreased connectivity between the hippocampus and the right superior frontal gyrus and increased connectivity between the hippocampus and the left superior temporal sulcus. Capturing changes in hippocampal functional connectivity during key developmental periods may elucidate how lifestyle factors including physical activity influence brain network connectivity trajectories, cognitive development, and future disease risk. |
| first_indexed | 2024-03-09T16:58:49Z |
| format | Article |
| id | doaj.art-9fc23b36e9254d5888f0b587887d41dd |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T16:58:49Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-9fc23b36e9254d5888f0b587887d41dd2023-11-24T14:32:44ZengMDPI AGBrain Sciences2076-34252023-11-011311155810.3390/brainsci13111558Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent ChildrenAbi Heller-Wight0Connor Phipps1Jennifer Sexton2Meghan Ramirez3David E. Warren4Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USAPeriadolescence is a neurodevelopmental period characterized by structural and functional brain changes that are associated with cognitive maturation. The development of the functional connectivity of the hippocampus contributes to cognitive maturation, especially memory processes. Notably, hippocampal development is influenced by lifestyle factors, including physical activity. Physical activity has been associated with individual variability in hippocampal functional connectivity. However, this relationship has not been characterized in a developmental cohort. In this study, we aimed to fill this gap by investigating the relationship between physical activity and the functional connectivity of the hippocampus in a cohort of periadolescents aged 8–13 years (N = 117). The participants completed a physical activity questionnaire, reporting the number of days per week they performed 60 min of physical activity; then, they completed a resting-state functional MRI scan. We observed that greater physical activity was significantly associated with differences in hippocampal functional connectivity in frontal and temporal regions. Greater physical activity was associated with decreased connectivity between the hippocampus and the right superior frontal gyrus and increased connectivity between the hippocampus and the left superior temporal sulcus. Capturing changes in hippocampal functional connectivity during key developmental periods may elucidate how lifestyle factors including physical activity influence brain network connectivity trajectories, cognitive development, and future disease risk.https://www.mdpi.com/2076-3425/13/11/1558hippocampusfunctional connectivitydevelopmentphysical activitymagnetic resonance imaging |
| spellingShingle | Abi Heller-Wight Connor Phipps Jennifer Sexton Meghan Ramirez David E. Warren Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children Brain Sciences hippocampus functional connectivity development physical activity magnetic resonance imaging |
| title | Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children |
| title_full | Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children |
| title_fullStr | Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children |
| title_full_unstemmed | Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children |
| title_short | Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children |
| title_sort | hippocampal resting state functional connectivity associated with physical activity in periadolescent children |
| topic | hippocampus functional connectivity development physical activity magnetic resonance imaging |
| url | https://www.mdpi.com/2076-3425/13/11/1558 |
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