Resiniferatoxin for detrusor instability refractory to anticholinergics
PURPOSE: We have evaluated the clinical and urodynamic effects of intravesical instillation of resiniferatoxin in patients with idiopathic detrusor instability refractory to anticholinergics. MATERIALS AND METHODS: There were 30 women, median age 56 years old with detrusor instability for over 6 mon...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Urologia
2004-02-01
|
| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382004000100012 |
| _version_ | 1819037768623325184 |
|---|---|
| author | Paulo C.R. Palma Marcelo Thiel Cássio L.Z. Riccetto Miriam Dambros Ricardo Miyaoka N. Rodrigues Netto Jr |
| author_facet | Paulo C.R. Palma Marcelo Thiel Cássio L.Z. Riccetto Miriam Dambros Ricardo Miyaoka N. Rodrigues Netto Jr |
| author_sort | Paulo C.R. Palma |
| collection | DOAJ |
| description | PURPOSE: We have evaluated the clinical and urodynamic effects of intravesical instillation of resiniferatoxin in patients with idiopathic detrusor instability refractory to anticholinergics. MATERIALS AND METHODS: There were 30 women, median age 56 years old with detrusor instability for over 6 months and a history of anticholinergic use with no response or intolerable collateral effects. A 50 nM solution of resiniferatoxin was prepared for intravesical instillation. All patients were evaluated for urinary symptoms, as well as for urodynamic assessments before and 30 days after instillation. Tolerability was analyzed during the instillation. RESULTS: A clinical improvement was observed in 30% of the patients with urinary urgency and in 33% of the patients with urge-incontinence. The mean maximum cystometric capacity before application was 303.9 ± 78.9 and after application 341 ± 84.6. No significant difference was observed (p = 0.585). The mean maximum amplitude of the contractions diminished from 47.86 ± 29.64 to 38.72 ± 30.77 (p = 0.002). CONCLUSIONS: Resiniferatoxin, in this concentration, proved to be useful in a small percentage of patients regarding clinical detrusor instability. Maximum amplitude of the involuntary contractions was significantly reduced and in 33% patients the involuntary contractions disappeared. Further studies with different concentrations are recommended. |
| first_indexed | 2024-12-21T08:26:40Z |
| format | Article |
| id | doaj.art-9fc5a223f94b49adadf0d487e2adb3ac |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-12-21T08:26:40Z |
| publishDate | 2004-02-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-9fc5a223f94b49adadf0d487e2adb3ac2022-12-21T19:10:19ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192004-02-01301535810.1590/S1677-55382004000100012Resiniferatoxin for detrusor instability refractory to anticholinergicsPaulo C.R. PalmaMarcelo ThielCássio L.Z. RiccettoMiriam DambrosRicardo MiyaokaN. Rodrigues Netto JrPURPOSE: We have evaluated the clinical and urodynamic effects of intravesical instillation of resiniferatoxin in patients with idiopathic detrusor instability refractory to anticholinergics. MATERIALS AND METHODS: There were 30 women, median age 56 years old with detrusor instability for over 6 months and a history of anticholinergic use with no response or intolerable collateral effects. A 50 nM solution of resiniferatoxin was prepared for intravesical instillation. All patients were evaluated for urinary symptoms, as well as for urodynamic assessments before and 30 days after instillation. Tolerability was analyzed during the instillation. RESULTS: A clinical improvement was observed in 30% of the patients with urinary urgency and in 33% of the patients with urge-incontinence. The mean maximum cystometric capacity before application was 303.9 ± 78.9 and after application 341 ± 84.6. No significant difference was observed (p = 0.585). The mean maximum amplitude of the contractions diminished from 47.86 ± 29.64 to 38.72 ± 30.77 (p = 0.002). CONCLUSIONS: Resiniferatoxin, in this concentration, proved to be useful in a small percentage of patients regarding clinical detrusor instability. Maximum amplitude of the involuntary contractions was significantly reduced and in 33% patients the involuntary contractions disappeared. Further studies with different concentrations are recommended.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382004000100012bladderurodynamicsurination disordersbladder instillationstoxins |
| spellingShingle | Paulo C.R. Palma Marcelo Thiel Cássio L.Z. Riccetto Miriam Dambros Ricardo Miyaoka N. Rodrigues Netto Jr Resiniferatoxin for detrusor instability refractory to anticholinergics International Brazilian Journal of Urology bladder urodynamics urination disorders bladder instillations toxins |
| title | Resiniferatoxin for detrusor instability refractory to anticholinergics |
| title_full | Resiniferatoxin for detrusor instability refractory to anticholinergics |
| title_fullStr | Resiniferatoxin for detrusor instability refractory to anticholinergics |
| title_full_unstemmed | Resiniferatoxin for detrusor instability refractory to anticholinergics |
| title_short | Resiniferatoxin for detrusor instability refractory to anticholinergics |
| title_sort | resiniferatoxin for detrusor instability refractory to anticholinergics |
| topic | bladder urodynamics urination disorders bladder instillations toxins |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382004000100012 |
| work_keys_str_mv | AT paulocrpalma resiniferatoxinfordetrusorinstabilityrefractorytoanticholinergics AT marcelothiel resiniferatoxinfordetrusorinstabilityrefractorytoanticholinergics AT cassiolzriccetto resiniferatoxinfordetrusorinstabilityrefractorytoanticholinergics AT miriamdambros resiniferatoxinfordetrusorinstabilityrefractorytoanticholinergics AT ricardomiyaoka resiniferatoxinfordetrusorinstabilityrefractorytoanticholinergics AT nrodriguesnettojr resiniferatoxinfordetrusorinstabilityrefractorytoanticholinergics |