Hemostasis at various stages of chronic pulmonary heart development
Aim. To study hemostasis and blood rheology in patients with chronic obstructive pulmonary disease (COPD), during chronic pulmonary heart (CPH) development and heart failure (HF) progression. Material and methods. In total, 54 COPD patients (mean age 56.3±8.2 years) were examined: Group I – 17 COPD...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2006-04-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1155 |
| _version_ | 1827064104848719872 |
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| author | A. I. Chesnikova |
| author_facet | A. I. Chesnikova |
| author_sort | A. I. Chesnikova |
| collection | DOAJ |
| description | Aim. To study hemostasis and blood rheology in patients with chronic obstructive pulmonary disease (COPD), during chronic pulmonary heart (CPH) development and heart failure (HF) progression. Material and methods. In total, 54 COPD patients (mean age 56.3±8.2 years) were examined: Group I – 17 COPD patients without CPH; Group II - 17 COPD patients with compensated CPH; Group III – 20 COPD patients with CHD and chronic HF (CHF). Control group consisted of 16 healthy volunteers. Vascular-platelet hemostasis parameters: platelet number, spontaneous platelet aggregation, induced aggregation activity and disaggregation potential; plasma hemostasis: coagulation, anticoagulation, and fibrinolysis components; blood rheology: hematocrit, free red cell sedimentation, red cell aggregation - were measured. Results. In COPD patients, moderately decompensated chronic syndrome of disseminated intravascular coagulation (DIC syndrome), leading to microcirculation pathology, was observed. In CPH pathogenesis, microthrombogenesis progression, pulmonary microcirculation abnormalities, pulmonary hypertension progression play an important role. In patients with COPD and CPH, hemostasis was characterized by decompensated DIC syndrome. Compensatory potential of secondary fibrinolysis was substantially decreased at local, organ level. Conclusion. The study demonstrated a leading role of hemostasis in CPH pathogenesis and CHF progression among COPD patients. Disbalance between microthrombosis and secondary organ fibrinolysis could be regarded as CHF marker in COPD individuals. |
| first_indexed | 2024-04-10T03:40:45Z |
| format | Article |
| id | doaj.art-9fc774e7fda64ab1be1a6ff170af4667 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2025-03-19T22:41:51Z |
| publishDate | 2006-04-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-9fc774e7fda64ab1be1a6ff170af46672024-10-17T12:21:23Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252006-04-01525056867Hemostasis at various stages of chronic pulmonary heart developmentA. I. Chesnikova0Rostov State Medical University. Rostov-na-DonuAim. To study hemostasis and blood rheology in patients with chronic obstructive pulmonary disease (COPD), during chronic pulmonary heart (CPH) development and heart failure (HF) progression. Material and methods. In total, 54 COPD patients (mean age 56.3±8.2 years) were examined: Group I – 17 COPD patients without CPH; Group II - 17 COPD patients with compensated CPH; Group III – 20 COPD patients with CHD and chronic HF (CHF). Control group consisted of 16 healthy volunteers. Vascular-platelet hemostasis parameters: platelet number, spontaneous platelet aggregation, induced aggregation activity and disaggregation potential; plasma hemostasis: coagulation, anticoagulation, and fibrinolysis components; blood rheology: hematocrit, free red cell sedimentation, red cell aggregation - were measured. Results. In COPD patients, moderately decompensated chronic syndrome of disseminated intravascular coagulation (DIC syndrome), leading to microcirculation pathology, was observed. In CPH pathogenesis, microthrombogenesis progression, pulmonary microcirculation abnormalities, pulmonary hypertension progression play an important role. In patients with COPD and CPH, hemostasis was characterized by decompensated DIC syndrome. Compensatory potential of secondary fibrinolysis was substantially decreased at local, organ level. Conclusion. The study demonstrated a leading role of hemostasis in CPH pathogenesis and CHF progression among COPD patients. Disbalance between microthrombosis and secondary organ fibrinolysis could be regarded as CHF marker in COPD individuals.https://cardiovascular.elpub.ru/jour/article/view/1155chronic obstructive pulmonary diseasechronic pulmonary heartheart failurehemostasis systemdisseminated intravascular coagulation syndromemicrohemocirculation |
| spellingShingle | A. I. Chesnikova Hemostasis at various stages of chronic pulmonary heart development Кардиоваскулярная терапия и профилактика chronic obstructive pulmonary disease chronic pulmonary heart heart failure hemostasis system disseminated intravascular coagulation syndrome microhemocirculation |
| title | Hemostasis at various stages of chronic pulmonary heart development |
| title_full | Hemostasis at various stages of chronic pulmonary heart development |
| title_fullStr | Hemostasis at various stages of chronic pulmonary heart development |
| title_full_unstemmed | Hemostasis at various stages of chronic pulmonary heart development |
| title_short | Hemostasis at various stages of chronic pulmonary heart development |
| title_sort | hemostasis at various stages of chronic pulmonary heart development |
| topic | chronic obstructive pulmonary disease chronic pulmonary heart heart failure hemostasis system disseminated intravascular coagulation syndrome microhemocirculation |
| url | https://cardiovascular.elpub.ru/jour/article/view/1155 |
| work_keys_str_mv | AT aichesnikova hemostasisatvariousstagesofchronicpulmonaryheartdevelopment |