Margin Assessment in Soft Tissue Sarcomas: Review of the Literature
Adequacy of margins must take into consideration both the resection margin width (quantity) and anatomic barrier (quality). There are several classification schemes for reporting surgical resection margin status for soft tissue sarcomas (STS). Most of the studies regarding treatment outcomes in STS...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/7/1687 |
| _version_ | 1797538977183432704 |
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| author | Andrea Sambri Emilia Caldari Michele Fiore Riccardo Zucchini Claudio Giannini Maria Giulia Pirini Paolo Spinnato Alberta Cappelli Davide Maria Donati Massimiliano De Paolis |
| author_facet | Andrea Sambri Emilia Caldari Michele Fiore Riccardo Zucchini Claudio Giannini Maria Giulia Pirini Paolo Spinnato Alberta Cappelli Davide Maria Donati Massimiliano De Paolis |
| author_sort | Andrea Sambri |
| collection | DOAJ |
| description | Adequacy of margins must take into consideration both the resection margin width (quantity) and anatomic barrier (quality). There are several classification schemes for reporting surgical resection margin status for soft tissue sarcomas (STS). Most of the studies regarding treatment outcomes in STS included all histologic grades and histological subtypes, which include infiltrative and non-infiltrative subtypes and are very heterogeneous in terms of both histologic characteristics and treatment modalities (adjuvant treatments or not). This lack of consistency makes it difficult to compare results from study to study. Therefore, there is a great need for evidence-based standardization concerning the width of resection margins. The aim of this narrative review is to provide a comprehensive assessment of the literature on margins, and to highlight the need for a uniform description of the margin status for patients with STS. Patient cases should be discussed at multidisciplinary tumor boards and treatments should be individualized to clinical and demographic characteristics, which must include also a deep knowledge of specific histotypes behaviors, particularly infiltrative ones. |
| first_indexed | 2024-03-10T12:38:51Z |
| format | Article |
| id | doaj.art-9fc78bf6f36b4695956a9d4b9414b407 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T12:38:51Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9fc78bf6f36b4695956a9d4b9414b4072023-11-21T14:04:18ZengMDPI AGCancers2072-66942021-04-01137168710.3390/cancers13071687Margin Assessment in Soft Tissue Sarcomas: Review of the LiteratureAndrea Sambri0Emilia Caldari1Michele Fiore2Riccardo Zucchini3Claudio Giannini4Maria Giulia Pirini5Paolo Spinnato6Alberta Cappelli7Davide Maria Donati8Massimiliano De Paolis9Alma Mater Studiorum, University of Bologna, 40126 Bologna, ItalyIRCCS Policlinico di Sant’Orsola, 40138 Bologna, ItalyIRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyIRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyIRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyIRCCS Policlinico di Sant’Orsola, 40138 Bologna, ItalyIRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyIRCCS Policlinico di Sant’Orsola, 40138 Bologna, ItalyAlma Mater Studiorum, University of Bologna, 40126 Bologna, ItalyIRCCS Policlinico di Sant’Orsola, 40138 Bologna, ItalyAdequacy of margins must take into consideration both the resection margin width (quantity) and anatomic barrier (quality). There are several classification schemes for reporting surgical resection margin status for soft tissue sarcomas (STS). Most of the studies regarding treatment outcomes in STS included all histologic grades and histological subtypes, which include infiltrative and non-infiltrative subtypes and are very heterogeneous in terms of both histologic characteristics and treatment modalities (adjuvant treatments or not). This lack of consistency makes it difficult to compare results from study to study. Therefore, there is a great need for evidence-based standardization concerning the width of resection margins. The aim of this narrative review is to provide a comprehensive assessment of the literature on margins, and to highlight the need for a uniform description of the margin status for patients with STS. Patient cases should be discussed at multidisciplinary tumor boards and treatments should be individualized to clinical and demographic characteristics, which must include also a deep knowledge of specific histotypes behaviors, particularly infiltrative ones.https://www.mdpi.com/2072-6694/13/7/1687marginssoft tissue sarcomaclassificationinfiltrativelocal recurrence |
| spellingShingle | Andrea Sambri Emilia Caldari Michele Fiore Riccardo Zucchini Claudio Giannini Maria Giulia Pirini Paolo Spinnato Alberta Cappelli Davide Maria Donati Massimiliano De Paolis Margin Assessment in Soft Tissue Sarcomas: Review of the Literature Cancers margins soft tissue sarcoma classification infiltrative local recurrence |
| title | Margin Assessment in Soft Tissue Sarcomas: Review of the Literature |
| title_full | Margin Assessment in Soft Tissue Sarcomas: Review of the Literature |
| title_fullStr | Margin Assessment in Soft Tissue Sarcomas: Review of the Literature |
| title_full_unstemmed | Margin Assessment in Soft Tissue Sarcomas: Review of the Literature |
| title_short | Margin Assessment in Soft Tissue Sarcomas: Review of the Literature |
| title_sort | margin assessment in soft tissue sarcomas review of the literature |
| topic | margins soft tissue sarcoma classification infiltrative local recurrence |
| url | https://www.mdpi.com/2072-6694/13/7/1687 |
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