Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain

Abstract Background Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and specifically altered histone acetylation. Nevertheless,...

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Bibliographic Details
Main Authors: Lilah Toker, Gia T. Tran, Janani Sundaresan, Ole-Bjørn Tysnes, Guido Alves, Kristoffer Haugarvoll, Gonzalo S. Nido, Christian Dölle, Charalampos Tzoulis
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Neurodegeneration
Subjects:
H3K27
Epigenetics
Neurodegeneration
ChIP-seq
Sirtuin
Mitochondria
Online Access:https://doi.org/10.1186/s13024-021-00450-7

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