Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health
<p>Abstract</p> <p>Background</p> <p>Asthma is a common complex disease responsible for considerable morbidity and mortality, particularly in urban minority populations. The Mechanistic Indicators of Childhood Asthma study was designed to pilot an integrative approach i...
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| Format: | Article |
| Language: | English |
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BMC
2011-05-01
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| Series: | BMC Public Health |
| Online Access: | http://www.biomedcentral.com/1471-2458/11/344 |
| _version_ | 1818011672688721920 |
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| author | Johnson Markey Williams Ronald Neas Lucas Heidenfelder Brooke Reif David Andrews Gina Rhoney Scott Inmon Jefferson Williams Ann Hudgens Edward Gallagher Jane Özkaynak Haluk Edwards Stephen Hubal Elaine |
| author_facet | Johnson Markey Williams Ronald Neas Lucas Heidenfelder Brooke Reif David Andrews Gina Rhoney Scott Inmon Jefferson Williams Ann Hudgens Edward Gallagher Jane Özkaynak Haluk Edwards Stephen Hubal Elaine |
| author_sort | Johnson Markey |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Asthma is a common complex disease responsible for considerable morbidity and mortality, particularly in urban minority populations. The Mechanistic Indicators of Childhood Asthma study was designed to pilot an integrative approach in children's health research. The study incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease with etiology related to gene-environment interactions.</p> <p>Methods/Design</p> <p>205 non-asthmatic and asthmatic children, (9-12 years of age) from Detroit, Michigan were recruited. The study includes environmental measures (indoor and outdoor air, vacuum dust), biomarkers of exposure (cotinine, metals, total and allergen specific Immunoglobulin E, polycyclic aromatic hydrocarbons, volatile organic carbon metabolites) and clinical indicators of health outcome (immunological, cardiovascular and respiratory). In addition, blood gene expression and candidate SNP analyses were conducted.</p> <p>Discussion</p> <p>Based on an integrative design, the MICA study provides an opportunity to evaluate complex relationships between environmental factors, physiological biomarkers, genetic susceptibility and health outcomes.</p> <p>Project approval</p> <p>IRB Number 05-EPA-2637: The human subjects' research protocol was reviewed by the Institutional Review Board (IRB) of the University of North Carolina; the IRB of Westat, Inc., the IRB of the Henry Ford Health System; and EPA's Human Subjects' Research Review Official.</p> |
| first_indexed | 2024-04-14T06:11:29Z |
| format | Article |
| id | doaj.art-9fc7fa5d773944d983b160943161aa3b |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-14T06:11:29Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-9fc7fa5d773944d983b160943161aa3b2022-12-22T02:08:22ZengBMCBMC Public Health1471-24582011-05-0111134410.1186/1471-2458-11-344Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental healthJohnson MarkeyWilliams RonaldNeas LucasHeidenfelder BrookeReif DavidAndrews GinaRhoney ScottInmon JeffersonWilliams AnnHudgens EdwardGallagher JaneÖzkaynak HalukEdwards StephenHubal Elaine<p>Abstract</p> <p>Background</p> <p>Asthma is a common complex disease responsible for considerable morbidity and mortality, particularly in urban minority populations. The Mechanistic Indicators of Childhood Asthma study was designed to pilot an integrative approach in children's health research. The study incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease with etiology related to gene-environment interactions.</p> <p>Methods/Design</p> <p>205 non-asthmatic and asthmatic children, (9-12 years of age) from Detroit, Michigan were recruited. The study includes environmental measures (indoor and outdoor air, vacuum dust), biomarkers of exposure (cotinine, metals, total and allergen specific Immunoglobulin E, polycyclic aromatic hydrocarbons, volatile organic carbon metabolites) and clinical indicators of health outcome (immunological, cardiovascular and respiratory). In addition, blood gene expression and candidate SNP analyses were conducted.</p> <p>Discussion</p> <p>Based on an integrative design, the MICA study provides an opportunity to evaluate complex relationships between environmental factors, physiological biomarkers, genetic susceptibility and health outcomes.</p> <p>Project approval</p> <p>IRB Number 05-EPA-2637: The human subjects' research protocol was reviewed by the Institutional Review Board (IRB) of the University of North Carolina; the IRB of Westat, Inc., the IRB of the Henry Ford Health System; and EPA's Human Subjects' Research Review Official.</p>http://www.biomedcentral.com/1471-2458/11/344 |
| spellingShingle | Johnson Markey Williams Ronald Neas Lucas Heidenfelder Brooke Reif David Andrews Gina Rhoney Scott Inmon Jefferson Williams Ann Hudgens Edward Gallagher Jane Özkaynak Haluk Edwards Stephen Hubal Elaine Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health BMC Public Health |
| title | Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health |
| title_full | Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health |
| title_fullStr | Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health |
| title_full_unstemmed | Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health |
| title_short | Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health |
| title_sort | mechanistic indicators of childhood asthma mica study piloting an integrative design for evaluating environmental health |
| url | http://www.biomedcentral.com/1471-2458/11/344 |
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