Structural and functional brain changes in people with knee osteoarthritis: a scoping review
Background Knee osteoarthritis is a highly prevalent disease worldwide that leads to functional disability and chronic pain. It has been shown that not only changes are generated at the joint level in these individuals, but also neuroplastic changes are produced in different brain areas, especially...
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| Format: | Article |
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PeerJ Inc.
2023-09-01
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| Online Access: | https://peerj.com/articles/16003.pdf |
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| author | Joaquín Salazar-Méndez Iván Cuyul-Vásquez Nelson Viscay-Sanhueza Juan Morales-Verdugo Guillermo Mendez-Rebolledo Felipe Ponce-Fuentes Enrique Lluch-Girbés |
| author_facet | Joaquín Salazar-Méndez Iván Cuyul-Vásquez Nelson Viscay-Sanhueza Juan Morales-Verdugo Guillermo Mendez-Rebolledo Felipe Ponce-Fuentes Enrique Lluch-Girbés |
| author_sort | Joaquín Salazar-Méndez |
| collection | DOAJ |
| description | Background Knee osteoarthritis is a highly prevalent disease worldwide that leads to functional disability and chronic pain. It has been shown that not only changes are generated at the joint level in these individuals, but also neuroplastic changes are produced in different brain areas, especially in those areas related to pain perception, therefore, the objective of this research was to identify and compare the structural and functional brain changes in knee OA versus healthy subjects. Methodology Searches in MEDLINE (PubMed), EMBASE, WOS, CINAHL, SCOPUS, Health Source, and Epistemonikos databases were conducted to explore the available evidence on the structural and functional brain changes occurring in people with knee OA. Data were recorded on study characteristics, participant characteristics, and brain assessment techniques. The methodological quality of the studies was analysed with Newcastle Ottawa Scale. Results Sixteen studies met the inclusion criteria. A decrease volume of the gray matter in the insular region, parietal lobe, cingulate cortex, hippocampus, visual cortex, temporal lobe, prefrontal cortex, and basal ganglia was found in people with knee OA. However, the opposite occurred in the frontal lobe, nucleus accumbens, amygdala region and somatosensory cortex, where an increase in the gray matter volume was evidenced. Moreover, a decreased connectivity to the frontal lobe from the insula, cingulate cortex, parietal, and temporal areas, and an increase in connectivity from the insula to the prefrontal cortex, subcallosal area, and temporal lobe was shown. Conclusion All these findings are suggestive of neuroplastic changes affecting the pain matrix in people with knee OA. |
| first_indexed | 2024-03-09T04:09:51Z |
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| id | doaj.art-9fcae4195b1b402b926e4df89b78cf2f |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T04:09:51Z |
| publishDate | 2023-09-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-9fcae4195b1b402b926e4df89b78cf2f2023-12-03T14:01:57ZengPeerJ Inc.PeerJ2167-83592023-09-0111e1600310.7717/peerj.16003Structural and functional brain changes in people with knee osteoarthritis: a scoping reviewJoaquín Salazar-Méndez0Iván Cuyul-Vásquez1Nelson Viscay-Sanhueza2Juan Morales-Verdugo3Guillermo Mendez-Rebolledo4Felipe Ponce-Fuentes5Enrique Lluch-Girbés6Laboratorio de Investigación Somatosensorial y Motora, Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Talca, ChileDepartamento de Procesos Terapéuticos, Facultad de Ciencias de la Salud, Universidad Católica de Temuco, Temuco, ChileUnidad de medicina física y rehabilitación, Hospital Dr. Gustavo Fricke, Viña del Mar, ChileDepartamento de Ciencias Preclínicas, Facultad de Medicina, Universidad Católica del Maule, Talca, ChileLaboratorio de Investigación Somatosensorial y Motora, Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Talca, ChileFacultad de Medicina y Ciencias de la Salud, Escuela de Kinesiología, Universidad Mayor, Temuco, ChileDepartment of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Valencia, SpainBackground Knee osteoarthritis is a highly prevalent disease worldwide that leads to functional disability and chronic pain. It has been shown that not only changes are generated at the joint level in these individuals, but also neuroplastic changes are produced in different brain areas, especially in those areas related to pain perception, therefore, the objective of this research was to identify and compare the structural and functional brain changes in knee OA versus healthy subjects. Methodology Searches in MEDLINE (PubMed), EMBASE, WOS, CINAHL, SCOPUS, Health Source, and Epistemonikos databases were conducted to explore the available evidence on the structural and functional brain changes occurring in people with knee OA. Data were recorded on study characteristics, participant characteristics, and brain assessment techniques. The methodological quality of the studies was analysed with Newcastle Ottawa Scale. Results Sixteen studies met the inclusion criteria. A decrease volume of the gray matter in the insular region, parietal lobe, cingulate cortex, hippocampus, visual cortex, temporal lobe, prefrontal cortex, and basal ganglia was found in people with knee OA. However, the opposite occurred in the frontal lobe, nucleus accumbens, amygdala region and somatosensory cortex, where an increase in the gray matter volume was evidenced. Moreover, a decreased connectivity to the frontal lobe from the insula, cingulate cortex, parietal, and temporal areas, and an increase in connectivity from the insula to the prefrontal cortex, subcallosal area, and temporal lobe was shown. Conclusion All these findings are suggestive of neuroplastic changes affecting the pain matrix in people with knee OA.https://peerj.com/articles/16003.pdfChronic painOsteoarthritisMRIEEGNeuroplasticKOA |
| spellingShingle | Joaquín Salazar-Méndez Iván Cuyul-Vásquez Nelson Viscay-Sanhueza Juan Morales-Verdugo Guillermo Mendez-Rebolledo Felipe Ponce-Fuentes Enrique Lluch-Girbés Structural and functional brain changes in people with knee osteoarthritis: a scoping review PeerJ Chronic pain Osteoarthritis MRI EEG Neuroplastic KOA |
| title | Structural and functional brain changes in people with knee osteoarthritis: a scoping review |
| title_full | Structural and functional brain changes in people with knee osteoarthritis: a scoping review |
| title_fullStr | Structural and functional brain changes in people with knee osteoarthritis: a scoping review |
| title_full_unstemmed | Structural and functional brain changes in people with knee osteoarthritis: a scoping review |
| title_short | Structural and functional brain changes in people with knee osteoarthritis: a scoping review |
| title_sort | structural and functional brain changes in people with knee osteoarthritis a scoping review |
| topic | Chronic pain Osteoarthritis MRI EEG Neuroplastic KOA |
| url | https://peerj.com/articles/16003.pdf |
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