Olaparib Combined With Dacomitinib in Osimertinib-Resistant Brain and Leptomeningeal Metastases From Non-Small Cell Lung Cancer: A Case Report and Systematic Review

Olaparib Combined With Dacomitinib in Osimertinib-Resistant Brain and Leptomeningeal Metastases From Non-Small Cell Lung Cancer: A Case Report and Systematic Review

Lung cancer patients with brain and leptomeningeal metastases usually have poor prognosis. For those patients with EGFR mutations, osimertinib, a third-generation tyrosine kinase inhibitor (TKI), is the first choice of treatment. However, drug resistance to osimertinib frequently occurs; and to date...

Full description

Bibliographic Details
Main Authors:	Hui Zhang, Yong Wang, Huaguo Wu, Shizhen Zhou, Shuo Li, Xiangji Meng, Rongjie Tao, Jinming Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Series:	Frontiers in Oncology
Subjects:	olaparib dacomitinib osimertinib-resistant brain and leptomeningeal metastases non-small cell lung cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.877279/full

Similar Items

Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases
by: Mei-Mei Zheng, et al.
Published: (2022-05-01)

Remarkable response to dacomitinib in a patient with leptomeningeal carcinomatosis due to EGFR‐mutant non‐small cell lung cancer
by: Shun Mizusaki, et al.
Published: (2021-01-01)

Virtual screening of Osimertinib and Dacomitinib Analogues with potential activity on EGFR (T790M and l858R Mutations) for non-small cell lung cancer treatment
by: Leydis Luna Torres, et al.
Published: (2021-10-01)

Case Report: Dacomitinib May Not Benefit Patients Who Develop Rare Compound Mutations After Later-Line Osimertinib Treatment
by: Hong-Shuai Li, et al.
Published: (2021-04-01)

Efficacy and safety of osimertinib for leptomeningeal metastases from EGFR-mutant non-small cell lung cancer: a pooled analysis
by: Lei Wen, et al.
Published: (2023-08-01)

Osimertinib Improves overall survival of EGFR-mutant NSCLC patients with leptomeningeal metastases
by: Qiuyue Ye, et al.
Published: (2023-05-01)

Case Report: Dacomitinib Overcomes Osimertinib Resistance in NSCLC Patient Harboring L718Q Mutation: A Case Report
by: Qian Shen, et al.
Published: (2021-12-01)

Optimal first-line treatment for EGFR-mutated NSCLC: a comparative analysis of osimertinib and second-generation EGFR-TKIs
by: Hsu-Yuan Chen, et al.
Published: (2024-10-01)

Osimertinib is associated with improved outcomes in pre-treated non-small cell lung cancer leptomeningeal metastases: A systematic review and meta-analysis
by: David J.H. Bian, et al.
Published: (2024-05-01)

Salvage therapy of osimertinib plus anlotinib in advanced lung adenocarcinoma with leptomeningeal metastasis: A case report
by: Kai Wu, et al.
Published: (2022-01-01)

Efficacy of dacomitinib in patients with EGFR‐mutated NSCLC and brain metastases
by: Jinyao Zhang, et al.
Published: (2021-12-01)

Combination of Osimertinib and Olaparib Therapy to Treat Non-Small Cell Lung Cancer and High-Grade Serous Ovarian Carcinoma: A Case Report
by: Jane Lin, et al.
Published: (2024-01-01)

Heterogeneity or transformation? A whack‐a‐mole case of EGFR‐mutant lung adenocarcinoma and small cell carcinoma: A case report
by: Taira Ninomaru, et al.
Published: (2022-08-01)

Immunotherapy in NSCLC Patients With Brain and Leptomeningeal Metastases
by: Thomas Pierret, et al.
Published: (2022-04-01)

Significance of an epidermal growth factor receptor mutation in cerebrospinal fluid for leptomeningeal metastasis and successful treatment with osimertinib: A case report and literature review
by: Takeo Sakurai, et al.
Published: (2021-03-01)

Double-dose osimertinib combined with intrathecal injection of pemetrexed improves the efficacy of EGFR-mutant non-small cell lung cancer and leptomeningeal metastasis: case report and literature review
by: Wenjuan Zhong, et al.
Published: (2024-04-01)

A case report of endometrial adenocarcinoma with leptomeningeal metastases
by: Danial Fazilat‐Panah, et al.
Published: (2021-09-01)

Findings to Leptomeningeal Metastases in Lung Cancer: A Case Report
by: Thiago Rodrigo de Noronha, et al.
Published: (2019-01-01)

Comparison of the diagnostic value of liquid biopsy in leptomeningeal metastases: A systematic review and meta-analysis
by: Hanbin Wang, et al.
Published: (2022-12-01)

Potential benefit of osismertinib plus bevacizumab in leptomeningeal metastasis with EGFR mutant non-small-cell lung cancer
by: Yali Yi, et al.
Published: (2022-03-01)

Genomic alterations of cerebrospinal fluid cell-free DNA in leptomeningeal metastases of gastric cancer
by: Xin Chen, et al.
Published: (2023-05-01)

High-Dose Osimertinib for CNS Progression in EGFR+ NSCLC: A Multi-Institutional Experience
by: A.J. Piper-Vallillo, MD, et al.
Published: (2022-06-01)

Management of Leptomeningeal Metastases in Non-oncogene Addicted Non-small Cell Lung Cancer
by: Ana Turkaj, et al.
Published: (2018-07-01)

A Pilot Phase 1 Study of Intrathecal Pemetrexed for Refractory Leptomeningeal Metastases From Non-small-cell Lung Cancer
by: Zhenyu Pan, et al.
Published: (2019-08-01)

Development and validation of a nomogram to predict leptomeningeal metastases in lung adenocarcinoma: Cervical lymph node metastasis is an important association factor
by: Xiaoyu Hua, et al.
Published: (2024-05-01)

Rationale and design of a phase II trial of dacomitinib in advanced non-small cell lung cancer patients with uncommon epidermal growth factor receptor mutations: a prospective and single arm study (DANCE study)
by: Bo Zhang, et al.
Published: (2022-03-01)

Research Progress of Lung Cancer with Leptomeningeal Metastasis
by: Chunhua MA, et al.
Published: (2014-09-01)

Efficacy and safety of dacomitinib in treatment-naïve patients with advanced NSCLC harboring uncommon EGFR mutation: an ambispective cohort study
by: Xingxiang Pu, et al.
Published: (2023-10-01)

Efficacy of osimertinib for preventing leptomeningeal metastasis derived from advanced EGFR-mutated non-small cell lung cancer: a propensity-matched retrospective study
by: Xia Wang, et al.
Published: (2021-07-01)

Bedside ocular ultrasonography for diagnosing increased intracranial pressure in patients with leptomeningeal metastases from non‐small‐cell lung cancer
by: Cheng Jiang, et al.
Published: (2023-03-01)

Invasion of small cell lung cancer into the limbic system from leptomeningeal metastases
by: Hisao Higo, et al.
Published: (2021-01-01)

Network-targeting combination therapy of leptomeningeal glioblastoma using multiple synthetic lethal strategies: a case report
by: Michael P. Castro, et al.
Published: (2023-10-01)

Combination of Cytologic Findings and Circulating Tumor DNA From Cerebrospinal Fluid Revealed SCLC Transformation in Patients With Leptomeningeal Metastases of Lung Adenocarcinoma
by: Jia-Xin Lin, PhD, et al.
Published: (2024-09-01)

Prophylactic treatment of dacomitinib‐induced skin toxicities in epidermal growth factor receptor‐mutated non–small‐cell lung cancer: A multicenter, Phase II trial
by: Masahiro Iwasaku, et al.
Published: (2023-07-01)

Leptomeningeal metastases in high-grade adult glioma: development, diagnosis, management and outcomes in a series of 34 patients.
by: Christopher eDardis, et al.
Published: (2014-11-01)

Case Report of Complete Response to Olaparib in a Patient with Breast Cancer Brain Metastases
by: Kazuki Asazuma, et al.
Published: (2024-07-01)

Metástases nas leptomeninges da espinal medula num doente com carcinoma de céculas escamosas do pulmão Spinal leptomeningeal metastasis in a patient with squamous cell lung cancer
by: Banu Alicioglu, et al.
Published: (2008-12-01)

A real‐world study of dacomitinib in later‐line settings for advanced non‐small cell lung cancer patients harboring EGFR mutations
by: Hong‐Shuai Li, et al.
Published: (2022-02-01)

HER2+ esophageal carcinoma leptomeningeal metastases treated with intrathecal trastuzumab regimen
by: Scott A Wu, et al.
Published: (2023-09-01)

Multisequence MRI-based radiomics nomogram for early prediction of osimertinib resistance in patients with non-small cell lung cancer brain metastases
by: Xinna Lv, et al.
Published: (2023-12-01)