Chemoradiation in Nasopharyngeal Carcinoma: A 6-Year Experience in Tehran Cancer Institute
To determine the addition of value of neoadjuvant, concurrent and adjuvant chemotherapy to radiation in the treatment of nasopharyngeal carcinoma with regard to the overall survival (OS) and disease free survival (DFS) within a six year period in Tehran cancer institute. Files of all patients with n...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2011-01-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/3691 |
| _version_ | 1818059162322468864 |
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| author | Bita Kalaghchi Ali Kazemian Farnaz Amouzegar Hashemi Mehdi Aghili Farshid Farhan Peiman Haddad |
| author_facet | Bita Kalaghchi Ali Kazemian Farnaz Amouzegar Hashemi Mehdi Aghili Farshid Farhan Peiman Haddad |
| author_sort | Bita Kalaghchi |
| collection | DOAJ |
| description | To determine the addition of value of neoadjuvant, concurrent and adjuvant chemotherapy to radiation in the treatment of nasopharyngeal carcinoma with regard to the overall survival (OS) and disease free survival (DFS) within a six year period in Tehran cancer institute. Files of all patients with nasopharyngeal carcinoma treated by radiotherapy with or without concurrent chemotherapy in a curative setting in Tehran cancer institute during the period of 1999-2005 were retrospectively reviewed.. A total of 103 patients with nasopharyngeal carcinoma had been treated during the study period with radiotherapy or chemoradiotherapy in our institute. There were 29 (28.2%) females and 74 (71.8%) males. The median age at the time of radiotherapy was 47 years old (range 9-75 years). The patients were followed 2 to 76 months with a median follow-up of 14 months. Time of first recurrence after treatment was 3-44 months with a median of 10 months.. Survival in 2 groups of patients treated with radiotherapy alone or chemoradiation did not have a significant difference (P>0.1). Two-year survival in patients treated with or without adjuvant chemotherapy and had local recurrence after treatment did not have significant difference (P>0.1). Two-year survival in patients with or without local recurrence after treatment did not have significant difference (P>0.1). A beneficial affect or a survival benefit of adjuvant/neoadjuvant chemotherapy and concurrent chemoradiation was not observed in Iranian patients. |
| first_indexed | 2024-12-10T13:12:08Z |
| format | Article |
| id | doaj.art-9fcc56b54ab64ec2a21fe8c8d7acbe70 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-10T13:12:08Z |
| publishDate | 2011-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-9fcc56b54ab64ec2a21fe8c8d7acbe702022-12-22T01:47:39ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942011-01-01491Chemoradiation in Nasopharyngeal Carcinoma: A 6-Year Experience in Tehran Cancer InstituteBita Kalaghchi0Ali Kazemian1Farnaz Amouzegar Hashemi2Mehdi Aghili3Farshid Farhan4Peiman Haddad5Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.To determine the addition of value of neoadjuvant, concurrent and adjuvant chemotherapy to radiation in the treatment of nasopharyngeal carcinoma with regard to the overall survival (OS) and disease free survival (DFS) within a six year period in Tehran cancer institute. Files of all patients with nasopharyngeal carcinoma treated by radiotherapy with or without concurrent chemotherapy in a curative setting in Tehran cancer institute during the period of 1999-2005 were retrospectively reviewed.. A total of 103 patients with nasopharyngeal carcinoma had been treated during the study period with radiotherapy or chemoradiotherapy in our institute. There were 29 (28.2%) females and 74 (71.8%) males. The median age at the time of radiotherapy was 47 years old (range 9-75 years). The patients were followed 2 to 76 months with a median follow-up of 14 months. Time of first recurrence after treatment was 3-44 months with a median of 10 months.. Survival in 2 groups of patients treated with radiotherapy alone or chemoradiation did not have a significant difference (P>0.1). Two-year survival in patients treated with or without adjuvant chemotherapy and had local recurrence after treatment did not have significant difference (P>0.1). Two-year survival in patients with or without local recurrence after treatment did not have significant difference (P>0.1). A beneficial affect or a survival benefit of adjuvant/neoadjuvant chemotherapy and concurrent chemoradiation was not observed in Iranian patients.https://acta.tums.ac.ir/index.php/acta/article/view/3691Nasopharyngeal neoplasmsRadiotherapyChemotherapy |
| spellingShingle | Bita Kalaghchi Ali Kazemian Farnaz Amouzegar Hashemi Mehdi Aghili Farshid Farhan Peiman Haddad Chemoradiation in Nasopharyngeal Carcinoma: A 6-Year Experience in Tehran Cancer Institute Acta Medica Iranica Nasopharyngeal neoplasms Radiotherapy Chemotherapy |
| title | Chemoradiation in Nasopharyngeal Carcinoma: A 6-Year Experience in Tehran Cancer Institute |
| title_full | Chemoradiation in Nasopharyngeal Carcinoma: A 6-Year Experience in Tehran Cancer Institute |
| title_fullStr | Chemoradiation in Nasopharyngeal Carcinoma: A 6-Year Experience in Tehran Cancer Institute |
| title_full_unstemmed | Chemoradiation in Nasopharyngeal Carcinoma: A 6-Year Experience in Tehran Cancer Institute |
| title_short | Chemoradiation in Nasopharyngeal Carcinoma: A 6-Year Experience in Tehran Cancer Institute |
| title_sort | chemoradiation in nasopharyngeal carcinoma a 6 year experience in tehran cancer institute |
| topic | Nasopharyngeal neoplasms Radiotherapy Chemotherapy |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/3691 |
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