Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

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Hlavní autoři: Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2013-06-01
Edice:Neurobiology of Disease
Témata:
Oxidative stress
Redox
TPI deficiency
Triose phosphate isomerase
Glycolytic enzymopathy
Drosophila
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0969996113000119

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113000119

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