Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

תיאור מלא

מידע ביבליוגרפי
Main Authors: Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
פורמט: Article
שפה:English
יצא לאור: Elsevier 2013-06-01
סדרה:Neurobiology of Disease
נושאים:
Oxidative stress
Redox
TPI deficiency
Triose phosphate isomerase
Glycolytic enzymopathy
Drosophila
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S0969996113000119

אינטרנט

http://www.sciencedirect.com/science/article/pii/S0969996113000119

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