Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

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Bibliografske podrobnosti
Main Authors: Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
Format: Article
Jezik:English
Izdano: Elsevier 2013-06-01
Serija:Neurobiology of Disease
Teme:
Oxidative stress
Redox
TPI deficiency
Triose phosphate isomerase
Glycolytic enzymopathy
Drosophila
Online dostop:http://www.sciencedirect.com/science/article/pii/S0969996113000119

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113000119

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