Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency
Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...
| Main Authors: | , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Elsevier
2013-06-01
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| 叢編: | Neurobiology of Disease |
| 主題: | |
| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S0969996113000119 |