Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Early mitochondrial dysfunction leads to altered redox chemistry underlying pathogenesis of TPI deficiency

Triose phosphate isomerase (TPI) is responsible for the interconversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis. Point mutations in this gene are associated with a glycolytic enzymopathy called TPI deficiency. This study utilizes a Drosophila melanogaster model of T...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Stacy L. Hrizo, Isaac J. Fisher, Daniel R. Long, Joshua A. Hutton, Zhaohui Liu, Michael J. Palladino
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	Elsevier 2013-06-01
Цуврал:	Neurobiology of Disease
Нөхцлүүд:	Oxidative stress Redox TPI deficiency Triose phosphate isomerase Glycolytic enzymopathy Drosophila
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S0969996113000119

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