Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract
Cervical cancer is preventable because the carcinogenesis is slow and there are opportunities to detect precancerous lesions by Papanicolaou (Pap) smears, colposcopy, or HPV DNA tests and to treat them by antimicrobials, surgery or cold CO2 vapourization. We have earlier reported on the chemoprevent...
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Elsevier
2016-04-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947616301486 |
| _version_ | 1818538982175145984 |
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| author | Jayashree Vinay Joshi Sujata S. Jagtap Prajakta Hemant Paradkar Priya Walwatkar Hemant S. Paradkar Zubair M. Affandi Ashok D.B. Vaidya |
| author_facet | Jayashree Vinay Joshi Sujata S. Jagtap Prajakta Hemant Paradkar Priya Walwatkar Hemant S. Paradkar Zubair M. Affandi Ashok D.B. Vaidya |
| author_sort | Jayashree Vinay Joshi |
| collection | DOAJ |
| description | Cervical cancer is preventable because the carcinogenesis is slow and there are opportunities to detect precancerous lesions by Papanicolaou (Pap) smears, colposcopy, or HPV DNA tests and to treat them by antimicrobials, surgery or cold CO2 vapourization. We have earlier reported on the chemopreventive potential of integrated treatment with antimicrobials therapy followed by a standardized oral Turmeric Oil (TO) extract upto 12 weeks in women who had persistent Low-grade Squamous Intra-epithelial Lesion (LSIL) in their Pap smears. In this communication we report their post-therapy follow up for 36 months (N = 18) with Pap smears. We were also able to follow up for 36 months control cases (N = 10) who had only standard therapy with antimicrobials.
During 36 months of follow up none of the cases with integrated treatment, progressed to HSIL or cancer. Out of 15/18 cases which had a regression of Pap smear, all 15 remained free of LSIL from 6 to 36 months post-therapy showing persistent therapeutic effect of integrated therapy. In one case there was recurrence of LSIL in Pap smear, ten months post-therapy, which regressed to mild atypia after a second course of oral TO for 8 weeks.
In the control group, persistence of LSIL after antimicrobials was observed in Pap smears in 5/10 cases when followed up by Pap smears up to 36 months. This preliminary report indicates some post-therapeutic benefit with integrative treatment as compared to the use of antimicrobials alone. A large scale controlled study is warranted. |
| first_indexed | 2024-12-11T21:36:02Z |
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| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-12-11T21:36:02Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
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| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-9fd338e457604bccb5f4fefc592ba8592022-12-22T00:50:00ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762016-04-017210911210.1016/j.jaim.2016.06.002Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extractJayashree Vinay Joshi0Sujata S. Jagtap1Prajakta Hemant Paradkar2Priya Walwatkar3Hemant S. Paradkar4Zubair M. Affandi5Ashok D.B. Vaidya6Kasturba Health Society-Medical Research Center, Vile Parle West, Mumbai, 400056, IndiaAyurvidya Prasarak Mandal's Ayurved Mahavidyalaya, Sion, Mumbai, 400022, IndiaKasturba Health Society-Medical Research Center, Vile Parle West, Mumbai, 400056, IndiaAyurvidya Prasarak Mandal's Ayurved Mahavidyalaya, Sion, Mumbai, 400022, IndiaAyurvidya Prasarak Mandal's Ayurved Mahavidyalaya, Sion, Mumbai, 400022, IndiaKasturba Health Society-Medical Research Center, Vile Parle West, Mumbai, 400056, IndiaKasturba Health Society-Medical Research Center, Vile Parle West, Mumbai, 400056, IndiaCervical cancer is preventable because the carcinogenesis is slow and there are opportunities to detect precancerous lesions by Papanicolaou (Pap) smears, colposcopy, or HPV DNA tests and to treat them by antimicrobials, surgery or cold CO2 vapourization. We have earlier reported on the chemopreventive potential of integrated treatment with antimicrobials therapy followed by a standardized oral Turmeric Oil (TO) extract upto 12 weeks in women who had persistent Low-grade Squamous Intra-epithelial Lesion (LSIL) in their Pap smears. In this communication we report their post-therapy follow up for 36 months (N = 18) with Pap smears. We were also able to follow up for 36 months control cases (N = 10) who had only standard therapy with antimicrobials. During 36 months of follow up none of the cases with integrated treatment, progressed to HSIL or cancer. Out of 15/18 cases which had a regression of Pap smear, all 15 remained free of LSIL from 6 to 36 months post-therapy showing persistent therapeutic effect of integrated therapy. In one case there was recurrence of LSIL in Pap smear, ten months post-therapy, which regressed to mild atypia after a second course of oral TO for 8 weeks. In the control group, persistence of LSIL after antimicrobials was observed in Pap smears in 5/10 cases when followed up by Pap smears up to 36 months. This preliminary report indicates some post-therapeutic benefit with integrative treatment as compared to the use of antimicrobials alone. A large scale controlled study is warranted.http://www.sciencedirect.com/science/article/pii/S0975947616301486Cervical cancerCytologyPap smearTurmericIntegrated treatment |
| spellingShingle | Jayashree Vinay Joshi Sujata S. Jagtap Prajakta Hemant Paradkar Priya Walwatkar Hemant S. Paradkar Zubair M. Affandi Ashok D.B. Vaidya Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract Journal of Ayurveda and Integrative Medicine Cervical cancer Cytology Pap smear Turmeric Integrated treatment |
| title | Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract |
| title_full | Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract |
| title_fullStr | Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract |
| title_full_unstemmed | Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract |
| title_short | Cytologic follow up of Low-grade Squamous Intraepithelial Lesions in Pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract |
| title_sort | cytologic follow up of low grade squamous intraepithelial lesions in pap smears after integrated treatment with antimicrobials followed by oral turmeric oil extract |
| topic | Cervical cancer Cytology Pap smear Turmeric Integrated treatment |
| url | http://www.sciencedirect.com/science/article/pii/S0975947616301486 |
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