Platelet Count/Spleen Thickness Ratio and the Risk of Variceal Bleeding in Cirrhosis With Esophagogastric Varices
IntroductionThe platelet count/spleen thickness ratio (PC/ST ratio) is associated with the grade of esophagogastric varices (EGV) in cirrhotic patients, but little is known about its relationship with esophagogastric variceal bleeding (EGVB). The aim of this study was to investigate the association...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.870351/full |
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| author | Huimin Liu Huimin Liu Qun Zhang Fangyuan Gao Hao Yu Yuyong Jiang Xianbo Wang |
| author_facet | Huimin Liu Huimin Liu Qun Zhang Fangyuan Gao Hao Yu Yuyong Jiang Xianbo Wang |
| author_sort | Huimin Liu |
| collection | DOAJ |
| description | IntroductionThe platelet count/spleen thickness ratio (PC/ST ratio) is associated with the grade of esophagogastric varices (EGV) in cirrhotic patients, but little is known about its relationship with esophagogastric variceal bleeding (EGVB). The aim of this study was to investigate the association between the PC/ST ratio and the risk of EGVB within 1 year in cirrhotic patients.MethodsA total of 1,354 patients with cirrhosis who had EGV were enrolled in this cohort study. A logistic regression model was used to determine the association between the PC/ST ratio and the risk of EGVB within 1 year in patients with cirrhosis by adjusting the PC/ST ratio with all the important clinical variables and confounders.ResultsThe quartile values of the PC/ST ratio were 1.01, 1.36, and 1.98, respectively. The PC/ST ratio was an independent risk factor for variceal bleeding in cirrhotic patients with moderate or severe EGV. After adjusting for multiple variables, the relationship was still unchanged. The odds ratios of the first EGVB in these patients were 5.07-fold at non-adjustment and 3.28-fold after multivariate adjustment. The odds ratios of rebleeding in these patients from the lowest to the highest quartile were 2.34-fold at non-adjustment and 2.01-fold after multivariable adjustment. The PC/ST ratio ≤ 1.36 elevated the 1-year risk of first-time variceal bleeding or rebleeding in cirrhotic patients with moderate or severe EGV (All P < 0.05).ConclusionThe PC/ST ratio ≤ 1.36 is an independent risk factor for the onset of first bleeding or rebleeding in cirrhotic patients with moderate or severe EGV. |
| first_indexed | 2024-12-11T02:04:29Z |
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| language | English |
| last_indexed | 2024-12-11T02:04:29Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-9fd3c380557b4325894983cfd09ddd202022-12-22T01:24:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-07-01910.3389/fmed.2022.870351870351Platelet Count/Spleen Thickness Ratio and the Risk of Variceal Bleeding in Cirrhosis With Esophagogastric VaricesHuimin Liu0Huimin Liu1Qun Zhang2Fangyuan Gao3Hao Yu4Yuyong Jiang5Xianbo Wang6Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaDepartment of Traditional Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaIntroductionThe platelet count/spleen thickness ratio (PC/ST ratio) is associated with the grade of esophagogastric varices (EGV) in cirrhotic patients, but little is known about its relationship with esophagogastric variceal bleeding (EGVB). The aim of this study was to investigate the association between the PC/ST ratio and the risk of EGVB within 1 year in cirrhotic patients.MethodsA total of 1,354 patients with cirrhosis who had EGV were enrolled in this cohort study. A logistic regression model was used to determine the association between the PC/ST ratio and the risk of EGVB within 1 year in patients with cirrhosis by adjusting the PC/ST ratio with all the important clinical variables and confounders.ResultsThe quartile values of the PC/ST ratio were 1.01, 1.36, and 1.98, respectively. The PC/ST ratio was an independent risk factor for variceal bleeding in cirrhotic patients with moderate or severe EGV. After adjusting for multiple variables, the relationship was still unchanged. The odds ratios of the first EGVB in these patients were 5.07-fold at non-adjustment and 3.28-fold after multivariate adjustment. The odds ratios of rebleeding in these patients from the lowest to the highest quartile were 2.34-fold at non-adjustment and 2.01-fold after multivariable adjustment. The PC/ST ratio ≤ 1.36 elevated the 1-year risk of first-time variceal bleeding or rebleeding in cirrhotic patients with moderate or severe EGV (All P < 0.05).ConclusionThe PC/ST ratio ≤ 1.36 is an independent risk factor for the onset of first bleeding or rebleeding in cirrhotic patients with moderate or severe EGV.https://www.frontiersin.org/articles/10.3389/fmed.2022.870351/fullcirrhosisrisk of esophagogastric variceal bleedingplatelet countspleen thicknessesophagogastric varices |
| spellingShingle | Huimin Liu Huimin Liu Qun Zhang Fangyuan Gao Hao Yu Yuyong Jiang Xianbo Wang Platelet Count/Spleen Thickness Ratio and the Risk of Variceal Bleeding in Cirrhosis With Esophagogastric Varices Frontiers in Medicine cirrhosis risk of esophagogastric variceal bleeding platelet count spleen thickness esophagogastric varices |
| title | Platelet Count/Spleen Thickness Ratio and the Risk of Variceal Bleeding in Cirrhosis With Esophagogastric Varices |
| title_full | Platelet Count/Spleen Thickness Ratio and the Risk of Variceal Bleeding in Cirrhosis With Esophagogastric Varices |
| title_fullStr | Platelet Count/Spleen Thickness Ratio and the Risk of Variceal Bleeding in Cirrhosis With Esophagogastric Varices |
| title_full_unstemmed | Platelet Count/Spleen Thickness Ratio and the Risk of Variceal Bleeding in Cirrhosis With Esophagogastric Varices |
| title_short | Platelet Count/Spleen Thickness Ratio and the Risk of Variceal Bleeding in Cirrhosis With Esophagogastric Varices |
| title_sort | platelet count spleen thickness ratio and the risk of variceal bleeding in cirrhosis with esophagogastric varices |
| topic | cirrhosis risk of esophagogastric variceal bleeding platelet count spleen thickness esophagogastric varices |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.870351/full |
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