Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia
The problem of Loa encephalopathy, which may occur after ivermectin treatment of patients harbouring high Loa microfilarial loads, might be solved if one could find a treatment regimen bringing about a significant but progressive decrease in the Loa microfilaraemia. A trial was performed in Central...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2002-03-01
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| Series: | Parasite |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/parasite/200209159 |
| _version_ | 1827616526531821568 |
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| author | Kamgno J. Boussinesq M. |
| author_facet | Kamgno J. Boussinesq M. |
| author_sort | Kamgno J. |
| collection | DOAJ |
| description | The problem of Loa encephalopathy, which may occur after ivermectin treatment of patients harbouring high Loa microfilarial loads, might be solved if one could find a treatment regimen bringing about a significant but progressive decrease in the Loa microfilaraemia. A trial was performed in Central Cameroon, whose aim was to follow up for 1 0 months, and to compare the changes in the Loa microfilarial loads in two groups of patients, one treated with a single dose (600 mg) of albendazole (Alben®, SmithKline Beecham) given with fatty food, and the other treated with mebendazole (100 mg, twice a day, generic tablets) at a fasting state. The microfilarial loads remained stable in the mebendazole group, whereas a significant decrease in microfilaraemia was recorded in the albendazole group (initial median load: 230 microfilariae per 50 μl; median load ten months after: 84 microfilariae per 50 μl). This should encourage further trials to evaluate the effects and the safely of two- or three-day albendazole regimens in patients infected with Loa loa. |
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| format | Article |
| id | doaj.art-9fd48d9121ca40498a46b71afbb99622 |
| institution | Directory Open Access Journal |
| issn | 1252-607X 1776-1042 |
| language | English |
| last_indexed | 2024-03-09T09:27:13Z |
| publishDate | 2002-03-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-9fd48d9121ca40498a46b71afbb996222023-12-02T05:33:25ZengEDP SciencesParasite1252-607X1776-10422002-03-0191596310.1051/parasite/200209159parasite2002091p59Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemiaKamgno J.Boussinesq M.The problem of Loa encephalopathy, which may occur after ivermectin treatment of patients harbouring high Loa microfilarial loads, might be solved if one could find a treatment regimen bringing about a significant but progressive decrease in the Loa microfilaraemia. A trial was performed in Central Cameroon, whose aim was to follow up for 1 0 months, and to compare the changes in the Loa microfilarial loads in two groups of patients, one treated with a single dose (600 mg) of albendazole (Alben®, SmithKline Beecham) given with fatty food, and the other treated with mebendazole (100 mg, twice a day, generic tablets) at a fasting state. The microfilarial loads remained stable in the mebendazole group, whereas a significant decrease in microfilaraemia was recorded in the albendazole group (initial median load: 230 microfilariae per 50 μl; median load ten months after: 84 microfilariae per 50 μl). This should encourage further trials to evaluate the effects and the safely of two- or three-day albendazole regimens in patients infected with Loa loa.http://dx.doi.org/10.1051/parasite/200209159albendazoleLoa loaloiasisonchocerciasisclinical trialivermectinside effects |
| spellingShingle | Kamgno J. Boussinesq M. Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia Parasite albendazole Loa loa loiasis onchocerciasis clinical trial ivermectin side effects |
| title | Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia |
| title_full | Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia |
| title_fullStr | Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia |
| title_full_unstemmed | Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia |
| title_short | Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia |
| title_sort | effect of a single dose 600 mg of albendazole on loa loa microfilaraemia |
| topic | albendazole Loa loa loiasis onchocerciasis clinical trial ivermectin side effects |
| url | http://dx.doi.org/10.1051/parasite/200209159 |
| work_keys_str_mv | AT kamgnoj effectofasingledose600mgofalbendazoleonloaloamicrofilaraemia AT boussinesqm effectofasingledose600mgofalbendazoleonloaloamicrofilaraemia |