DNA Polymerase ζ without the C-Terminus of Catalytic Subunit Rev3 Retains Characteristic Activity, but Alters Mutation Specificity of Ultraviolet Radiation in Yeast

DNA Polymerase ζ without the C-Terminus of Catalytic Subunit Rev3 Retains Characteristic Activity, but Alters Mutation Specificity of Ultraviolet Radiation in Yeast

DNA polymerase ζ (pol ζ) plays a central role in replicating damaged genomic DNA. When DNA synthesis stalls at a lesion, it participates in translesion DNA synthesis (TLS), which helps replication proceed. TLS prevents cell death at the expense of new mutations. The current model indicates that pol...

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Bibliographic Details
Main Authors: Hollie M. Siebler, Jian Cui, Sarah E. Hill, Youri I. Pavlov
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Genes
Subjects:
UV mutagenesis
mutation spectra
pol ζ
TLS
Online Access:https://www.mdpi.com/2073-4425/13/9/1576

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