Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) is arguably the most common benign disease among men. This disease is often associated with lower urinary tract symptoms (LUTS) in men and significantly decreases the quality of life. Polyphenol consumption reportedly plays an important role in the prevention of ma...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/1420-3049/26/2/450 |
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| author | Kensuke Mitsunari Yasuyoshi Miyata Tomohiro Matsuo Yuta Mukae Asato Otsubo Junki Harada Tsubasa Kondo Tsuyoshi Matsuda Kojiro Ohba Hideki Sakai |
| author_facet | Kensuke Mitsunari Yasuyoshi Miyata Tomohiro Matsuo Yuta Mukae Asato Otsubo Junki Harada Tsubasa Kondo Tsuyoshi Matsuda Kojiro Ohba Hideki Sakai |
| author_sort | Kensuke Mitsunari |
| collection | DOAJ |
| description | Benign prostatic hyperplasia (BPH) is arguably the most common benign disease among men. This disease is often associated with lower urinary tract symptoms (LUTS) in men and significantly decreases the quality of life. Polyphenol consumption reportedly plays an important role in the prevention of many diseases, including BPH. In recent years, in addition to disease prevention, many studies have reported the efficacy and safety of polyphenol treatment against various pathological conditions in vivo and in vitro. Furthermore, numerous studies have also revealed the molecular mechanisms of the antioxidant and anti-inflammatory effects of polyphenols. We believe that an improved understanding of the detailed pharmacological roles of polyphenol-induced activities at a molecular level is important for the prevention and treatment of BPH. Polyphenols are composed of many members, and their biological roles differ. In this review, we first provide information regarding the pathological roles of oxidative stress and inflammation in BPH. Next, the antioxidant and anti-inflammatory effects of polyphenols, including those of flavonoids and non-flavonoids, are discussed. Finally, we talk about the results and limitations of previous clinical trials that have used polyphenols in BPH, with particular focus on their molecular mechanisms of action. |
| first_indexed | 2024-03-09T04:35:06Z |
| format | Article |
| id | doaj.art-9fdcdfb721134321a3ede86f6207a7ed |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:35:06Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9fdcdfb721134321a3ede86f6207a7ed2023-12-03T13:29:49ZengMDPI AGMolecules1420-30492021-01-0126245010.3390/molecules26020450Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic HyperplasiaKensuke Mitsunari0Yasuyoshi Miyata1Tomohiro Matsuo2Yuta Mukae3Asato Otsubo4Junki Harada5Tsubasa Kondo6Tsuyoshi Matsuda7Kojiro Ohba8Hideki Sakai9Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanDepartment of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, JapanBenign prostatic hyperplasia (BPH) is arguably the most common benign disease among men. This disease is often associated with lower urinary tract symptoms (LUTS) in men and significantly decreases the quality of life. Polyphenol consumption reportedly plays an important role in the prevention of many diseases, including BPH. In recent years, in addition to disease prevention, many studies have reported the efficacy and safety of polyphenol treatment against various pathological conditions in vivo and in vitro. Furthermore, numerous studies have also revealed the molecular mechanisms of the antioxidant and anti-inflammatory effects of polyphenols. We believe that an improved understanding of the detailed pharmacological roles of polyphenol-induced activities at a molecular level is important for the prevention and treatment of BPH. Polyphenols are composed of many members, and their biological roles differ. In this review, we first provide information regarding the pathological roles of oxidative stress and inflammation in BPH. Next, the antioxidant and anti-inflammatory effects of polyphenols, including those of flavonoids and non-flavonoids, are discussed. Finally, we talk about the results and limitations of previous clinical trials that have used polyphenols in BPH, with particular focus on their molecular mechanisms of action.https://www.mdpi.com/1420-3049/26/2/450polyphenolsflavonoidspharmacological effectbenign prostatic hyperplasia |
| spellingShingle | Kensuke Mitsunari Yasuyoshi Miyata Tomohiro Matsuo Yuta Mukae Asato Otsubo Junki Harada Tsubasa Kondo Tsuyoshi Matsuda Kojiro Ohba Hideki Sakai Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia Molecules polyphenols flavonoids pharmacological effect benign prostatic hyperplasia |
| title | Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia |
| title_full | Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia |
| title_fullStr | Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia |
| title_full_unstemmed | Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia |
| title_short | Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia |
| title_sort | pharmacological effects and potential clinical usefulness of polyphenols in benign prostatic hyperplasia |
| topic | polyphenols flavonoids pharmacological effect benign prostatic hyperplasia |
| url | https://www.mdpi.com/1420-3049/26/2/450 |
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