Alterations of CSF cystatin C levels and their correlations with CSF Αβ40 and Αβ42 levels in patients with Alzheimer's disease, dementia with lewy bodies and the atrophic form of general paresis.

Alterations of CSF cystatin C levels and their correlations with CSF Αβ40 and Αβ42 levels in patients with Alzheimer's disease, dementia with lewy bodies and the atrophic form of general paresis.

Immunohistochemical studies have revealed that cystatin C (CysC) co-localizes with amyloid-β (Αβ) in amyloid-laden vascular walls and in the senile plaque cores of amyloid. In vitro and in vivo animal studies suggest that CysC protects against neurodegeneration by inhibition of cysteine proteases, i...

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Main Authors: Xiao-Mei Zhong, Le Hou, Xin-Ni Luo, Hai-Shan Shi, Guo-Yan Hu, Hong-Bo He, Xin-Ru Chen, Dong Zheng, Yue-Feng Zhang, Yan Tan, Xue-Jun Liu, Nan Mu, Jian-Ping Chen, Yu-Ping Ning
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3558470?pdf=render

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