Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth
The spatial distribution of neurons and activity-dependent neurite outgrowth shape long-range interaction, recurrent local connectivity and the modularity in neuronal networks. We investigated how this mesoscale architecture develops by interaction of neurite outgrowth, cell migration and activity i...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2019-09-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/47996 |
| _version_ | 1811180550266814464 |
|---|---|
| author | Samora Okujeni Ulrich Egert |
| author_facet | Samora Okujeni Ulrich Egert |
| author_sort | Samora Okujeni |
| collection | DOAJ |
| description | The spatial distribution of neurons and activity-dependent neurite outgrowth shape long-range interaction, recurrent local connectivity and the modularity in neuronal networks. We investigated how this mesoscale architecture develops by interaction of neurite outgrowth, cell migration and activity in cultured networks of rat cortical neurons and show that simple rules can explain variations of network modularity. In contrast to theoretical studies on activity-dependent outgrowth but consistent with predictions for modular networks, spontaneous activity and the rate of synchronized bursts increased with clustering, whereas peak firing rates in bursts increased in highly interconnected homogeneous networks. As Ca2+ influx increased exponentially with increasing network recruitment during bursts, its modulation was highly correlated to peak firing rates. During network maturation, long-term estimates of Ca2+ influx showed convergence, even for highly different mesoscale architectures, neurite extent, connectivity, modularity and average activity levels, indicating homeostatic regulation towards a common set-point of Ca2+ influx. |
| first_indexed | 2024-04-11T09:05:11Z |
| format | Article |
| id | doaj.art-9fde87c6dfaa4c54a0b04fde1ffc1abb |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:11Z |
| publishDate | 2019-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-9fde87c6dfaa4c54a0b04fde1ffc1abb2022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2019-09-01810.7554/eLife.47996Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowthSamora Okujeni0https://orcid.org/0000-0001-7924-3651Ulrich Egert1https://orcid.org/0000-0002-4583-0425Laboratory for Biomicrotechnology, Department of Microsystems Engineering—IMTEK, University of Freiburg, Freiburg, Germany; Bernstein Center Freiburg, University of Freiburg, Freiburg, GermanyLaboratory for Biomicrotechnology, Department of Microsystems Engineering—IMTEK, University of Freiburg, Freiburg, Germany; Bernstein Center Freiburg, University of Freiburg, Freiburg, GermanyThe spatial distribution of neurons and activity-dependent neurite outgrowth shape long-range interaction, recurrent local connectivity and the modularity in neuronal networks. We investigated how this mesoscale architecture develops by interaction of neurite outgrowth, cell migration and activity in cultured networks of rat cortical neurons and show that simple rules can explain variations of network modularity. In contrast to theoretical studies on activity-dependent outgrowth but consistent with predictions for modular networks, spontaneous activity and the rate of synchronized bursts increased with clustering, whereas peak firing rates in bursts increased in highly interconnected homogeneous networks. As Ca2+ influx increased exponentially with increasing network recruitment during bursts, its modulation was highly correlated to peak firing rates. During network maturation, long-term estimates of Ca2+ influx showed convergence, even for highly different mesoscale architectures, neurite extent, connectivity, modularity and average activity levels, indicating homeostatic regulation towards a common set-point of Ca2+ influx.https://elifesciences.org/articles/47996neurite outgrowthneuronal migrationnetwork structureactivity-dependent developmenthomeostatic regulationprotein kinase C |
| spellingShingle | Samora Okujeni Ulrich Egert Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth eLife neurite outgrowth neuronal migration network structure activity-dependent development homeostatic regulation protein kinase C |
| title | Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth |
| title_full | Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth |
| title_fullStr | Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth |
| title_full_unstemmed | Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth |
| title_short | Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth |
| title_sort | self organization of modular network architecture by activity dependent neuronal migration and outgrowth |
| topic | neurite outgrowth neuronal migration network structure activity-dependent development homeostatic regulation protein kinase C |
| url | https://elifesciences.org/articles/47996 |
| work_keys_str_mv | AT samoraokujeni selforganizationofmodularnetworkarchitecturebyactivitydependentneuronalmigrationandoutgrowth AT ulrichegert selforganizationofmodularnetworkarchitecturebyactivitydependentneuronalmigrationandoutgrowth |