Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study
Background: Cervical cancer is known to be a preventable cancer in which various risk factors play role in increasing the risk of the disease. In this study, we have assessed different risk factors involved in invasive cervical cancer in Northeast of Iran. Methods: In a case control study, 100 pa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-01-01
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| Series: | Basic & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/355 |
| _version_ | 1818872879920447488 |
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| author | Fatemeh Homaei Shandiz Alireza Pasdar Fahimeh Afzaljavan Zohre Takalluo Malihe Hasanzadeh Mofrad |
| author_facet | Fatemeh Homaei Shandiz Alireza Pasdar Fahimeh Afzaljavan Zohre Takalluo Malihe Hasanzadeh Mofrad |
| author_sort | Fatemeh Homaei Shandiz |
| collection | DOAJ |
| description | Background: Cervical cancer is known to be a preventable cancer in which various risk factors play role in increasing the risk of the disease. In this study, we have assessed different risk factors involved in invasive cervical cancer in Northeast of Iran.
Methods: In a case control study, 100 patients with advanced cervical cancer were compared to 100 healthy, normal women. In addition, 100 cases of prisoner women who had a high risk profile for cervical cancer were also investigated. Cervical risk factors for these groups were documented using a questionnaire and available medical notes. Univariate analysis was done for each risk factor followed by a multivariate regression analysis to evaluate the most powerful risk factors after adjustment.
Result: Age of first intercourse ≤16 (P<0.001)[OR= 4.18, 95% CI (2.32-7.54)], sexually transmitted diseases (STD) (P<0.001) [OR=8.59,95% CI (4.25-17.37)], passive smoking (P<0.01) [OR= 2.35, 95% CI (1.17-4.72)], smoking (P<0.01) [OR=10.33, 95% CI (2.32-46.17)], age of first pregnancy ≤17 years (P<0.001) [OR= 3.37, 95% CI (1.79-6.33)] were strongly related to the occurrence of cervical cancer. However, STD remained statistically significant (P<0.01) after adjustment. |
| first_indexed | 2024-12-19T12:45:50Z |
| format | Article |
| id | doaj.art-9fe25db284544a46b4997c98f4328875 |
| institution | Directory Open Access Journal |
| issn | 2228-6527 2228-5466 |
| language | English |
| last_indexed | 2024-12-19T12:45:50Z |
| publishDate | 2021-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj.art-9fe25db284544a46b4997c98f43288752022-12-21T20:20:46ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662021-01-0112210.18502/bccr.v12i2.5754Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control StudyFatemeh Homaei Shandiz0Alireza Pasdar1Fahimeh Afzaljavan2Zohre Takalluo3Malihe Hasanzadeh Mofrad4Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Obstetrics and Gynecology, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences.Department of Obstetrics and Gynecology, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences.Background: Cervical cancer is known to be a preventable cancer in which various risk factors play role in increasing the risk of the disease. In this study, we have assessed different risk factors involved in invasive cervical cancer in Northeast of Iran. Methods: In a case control study, 100 patients with advanced cervical cancer were compared to 100 healthy, normal women. In addition, 100 cases of prisoner women who had a high risk profile for cervical cancer were also investigated. Cervical risk factors for these groups were documented using a questionnaire and available medical notes. Univariate analysis was done for each risk factor followed by a multivariate regression analysis to evaluate the most powerful risk factors after adjustment. Result: Age of first intercourse ≤16 (P<0.001)[OR= 4.18, 95% CI (2.32-7.54)], sexually transmitted diseases (STD) (P<0.001) [OR=8.59,95% CI (4.25-17.37)], passive smoking (P<0.01) [OR= 2.35, 95% CI (1.17-4.72)], smoking (P<0.01) [OR=10.33, 95% CI (2.32-46.17)], age of first pregnancy ≤17 years (P<0.001) [OR= 3.37, 95% CI (1.79-6.33)] were strongly related to the occurrence of cervical cancer. However, STD remained statistically significant (P<0.01) after adjustment.https://bccr.tums.ac.ir/index.php/bccrj/article/view/355cervical cancerSexually transmitted diseasesrisk factorssexual behavior |
| spellingShingle | Fatemeh Homaei Shandiz Alireza Pasdar Fahimeh Afzaljavan Zohre Takalluo Malihe Hasanzadeh Mofrad Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study Basic & Clinical Cancer Research cervical cancer Sexually transmitted diseases risk factors sexual behavior |
| title | Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study |
| title_full | Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study |
| title_fullStr | Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study |
| title_full_unstemmed | Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study |
| title_short | Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study |
| title_sort | major risk factors for cervical cancer in northeast of iran evidence from a case control study |
| topic | cervical cancer Sexually transmitted diseases risk factors sexual behavior |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/355 |
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