Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4). Prompted by a recent failure to find...

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Bibliographic Details
Main Authors: Humberto Mestre, Lauren M Hablitz, Anna LR Xavier, Weixi Feng, Wenyan Zou, Tinglin Pu, Hiromu Monai, Giridhar Murlidharan, Ruth M Castellanos Rivera, Matthew J Simon, Martin M Pike, Virginia Plá, Ting Du, Benjamin T Kress, Xiaowen Wang, Benjamin A Plog, Alexander S Thrane, Iben Lundgaard, Yoichiro Abe, Masato Yasui, John H Thomas, Ming Xiao, Hajime Hirase, Aravind Asokan, Jeffrey J Iliff, Maiken Nedergaard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
aquaporin-4
glymphatic
solute transport
cerebrospinal fluid
replication study
meta-analysis
Online Access:https://elifesciences.org/articles/40070

Internet

https://elifesciences.org/articles/40070

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