Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomy
Objective:The aim of this study was to investigate the potential relationship between biochemical progression and prognostic risk factors in patients with prostate cancer (PCa) patients undergoing radical prostatectomy (RP).Materials and Methods:After inclusion/exclusion criteria were applied, 216 p...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-09-01
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| Series: | Journal of Urological Surgery |
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http://jurolsurgery.org/archives/archive-detail/article-preview/evaluation-of-risk-groups-for-the-prediction-of-bi/52942
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| _version_ | 1828024153079283712 |
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| author | Serdar Madendere Görkem Türkkan Ersan Arda Vuslat Yürüt Çaloğlu Uğur Kuyumcuoğlu |
| author_facet | Serdar Madendere Görkem Türkkan Ersan Arda Vuslat Yürüt Çaloğlu Uğur Kuyumcuoğlu |
| author_sort | Serdar Madendere |
| collection | DOAJ |
| description | Objective:The aim of this study was to investigate the potential relationship between biochemical progression and prognostic risk factors in patients with prostate cancer (PCa) patients undergoing radical prostatectomy (RP).Materials and Methods:After inclusion/exclusion criteria were applied, 216 patients who underwent RP were included in this study. Follow-up protocol included prostate specific antigen (PSA) measurements; every 3 months for the first year, every 6 months for the second year, and an annual check after 2 years. Preoperative and postoperative PSA measurements, pathological stage, Gleason score (GS), extraprostatic extension, positive surgical margins and seminal vesicle invasion were evaluated. Uni- and multivariable analyses were used to detect the relationship between biochemical progression, biochemical progression-free survival (BPFS) and prognostic risk factors.Results:Median follow-up was 29 months. Biochemical progression was observed in 39 (18.1%) patients, in 18 (9.7%) of 185 patients with first postoperative PSA level of <0.2 ng/dL, and 21 (67.7%) of 31 patients with first postoperative PSA level of ≥0.2 ng/dL. Patients with first postoperative PSA level of ≥0.2 ng/dL had a statistically significant higher risk of biochemical progression and shorter BPFS (odds ratio: 2.41; 95% confidence interval: 1.84-3.10; p<0.001), in univariate and multivariate analyses. Patients with GS ≥8 or T3-4 or positive surgical margins had a statistically significant higher risk of biochemical progression (p<0.001, p=0.003, p<0.001).Conclusion:Postoperative PSA level higher than ≥0.2 ng/dL was the most important predictor of biochemical progression and BPFS after RP. GS ≥8, T3-4 stages, and positive surgical margins are also related to biochemical progression. |
| first_indexed | 2024-04-10T12:40:48Z |
| format | Article |
| id | doaj.art-9fe3b240c0bc405da7f8fd9921e6b32e |
| institution | Directory Open Access Journal |
| issn | 2148-9580 |
| language | English |
| last_indexed | 2024-04-10T12:40:48Z |
| publishDate | 2022-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Urological Surgery |
| spelling | doaj.art-9fe3b240c0bc405da7f8fd9921e6b32e2023-02-15T16:14:20ZengGalenos YayineviJournal of Urological Surgery2148-95802022-09-019315916410.4274/jus.galenos.2021.2021.009813049054Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical ProstatectomySerdar Madendere0Görkem Türkkan1Ersan Arda2Vuslat Yürüt Çaloğlu3Uğur Kuyumcuoğlu4 Trakya University Faculty of Medicine, Department of Urology, Edirne, Turkiye İstinye University Faculty of Medicine, Department of Radiation Oncology, Istanbul, Turkiye Trakya University Faculty of Medicine, Department of Urology, Edirne, Turkiye Trakya University Faculty of Medicine, Department of Radiation Oncology, Edirne, Turkiye Trakya University Faculty of Medicine, Department of Urology, Edirne, Turkiye Objective:The aim of this study was to investigate the potential relationship between biochemical progression and prognostic risk factors in patients with prostate cancer (PCa) patients undergoing radical prostatectomy (RP).Materials and Methods:After inclusion/exclusion criteria were applied, 216 patients who underwent RP were included in this study. Follow-up protocol included prostate specific antigen (PSA) measurements; every 3 months for the first year, every 6 months for the second year, and an annual check after 2 years. Preoperative and postoperative PSA measurements, pathological stage, Gleason score (GS), extraprostatic extension, positive surgical margins and seminal vesicle invasion were evaluated. Uni- and multivariable analyses were used to detect the relationship between biochemical progression, biochemical progression-free survival (BPFS) and prognostic risk factors.Results:Median follow-up was 29 months. Biochemical progression was observed in 39 (18.1%) patients, in 18 (9.7%) of 185 patients with first postoperative PSA level of <0.2 ng/dL, and 21 (67.7%) of 31 patients with first postoperative PSA level of ≥0.2 ng/dL. Patients with first postoperative PSA level of ≥0.2 ng/dL had a statistically significant higher risk of biochemical progression and shorter BPFS (odds ratio: 2.41; 95% confidence interval: 1.84-3.10; p<0.001), in univariate and multivariate analyses. Patients with GS ≥8 or T3-4 or positive surgical margins had a statistically significant higher risk of biochemical progression (p<0.001, p=0.003, p<0.001).Conclusion:Postoperative PSA level higher than ≥0.2 ng/dL was the most important predictor of biochemical progression and BPFS after RP. GS ≥8, T3-4 stages, and positive surgical margins are also related to biochemical progression. http://jurolsurgery.org/archives/archive-detail/article-preview/evaluation-of-risk-groups-for-the-prediction-of-bi/52942 prostate cancerradical prostatectomybiochemical progression |
| spellingShingle | Serdar Madendere Görkem Türkkan Ersan Arda Vuslat Yürüt Çaloğlu Uğur Kuyumcuoğlu Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomy Journal of Urological Surgery prostate cancer radical prostatectomy biochemical progression |
| title | Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomy |
| title_full | Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomy |
| title_fullStr | Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomy |
| title_full_unstemmed | Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomy |
| title_short | Evaluation of Risk Groups for the Prediction of Biochemical Progression in Patients Undergoing Radical Prostatectomy |
| title_sort | evaluation of risk groups for the prediction of biochemical progression in patients undergoing radical prostatectomy |
| topic | prostate cancer radical prostatectomy biochemical progression |
| url |
http://jurolsurgery.org/archives/archive-detail/article-preview/evaluation-of-risk-groups-for-the-prediction-of-bi/52942
|
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