High speed photo-mediated ultrasound therapy integrated with OCTA
Abstract Photo-mediated Ultrasound Therapy (PUT), as a new anti-vascular technique, can promote cavitation activity to selectively destruct blood vessels with a significantly lower amount of energy when compared to energy level required by other laser and ultrasound treatment therapies individually....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23188-8 |
| _version_ | 1811319599178711040 |
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| author | Yan Li Yuchen Song Runze Li Wangcun Jia Fengyi Zhang Xiaoming Hu Lidek Chou Qifa Zhou Zhongping Chen |
| author_facet | Yan Li Yuchen Song Runze Li Wangcun Jia Fengyi Zhang Xiaoming Hu Lidek Chou Qifa Zhou Zhongping Chen |
| author_sort | Yan Li |
| collection | DOAJ |
| description | Abstract Photo-mediated Ultrasound Therapy (PUT), as a new anti-vascular technique, can promote cavitation activity to selectively destruct blood vessels with a significantly lower amount of energy when compared to energy level required by other laser and ultrasound treatment therapies individually. Here, we report the development of a high speed PUT system based on a 50-kHz pulsed laser to achieve faster treatment, decreasing the treatment time by a factor of 20. Furthermore, we integrated it with optical coherence tomography angiography (OCTA) for real time monitoring. The feasibility of the proposed OCTA-guided PUT was validated through in vivo rabbit experiments. The addition of OCTA to PUT allows for quantitative prescreening and real time monitoring of treatment response, thereby enabling implementation of individualized treatment strategies. |
| first_indexed | 2024-04-13T12:45:48Z |
| format | Article |
| id | doaj.art-9fe584206e2b44e8b07da9d599292d57 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T12:45:48Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9fe584206e2b44e8b07da9d599292d572022-12-22T02:46:22ZengNature PortfolioScientific Reports2045-23222022-11-011211610.1038/s41598-022-23188-8High speed photo-mediated ultrasound therapy integrated with OCTAYan Li0Yuchen Song1Runze Li2Wangcun Jia3Fengyi Zhang4Xiaoming Hu5Lidek Chou6Qifa Zhou7Zhongping Chen8Beckman Laser Institute, University of California, IrvineBeckman Laser Institute, University of California, IrvineDepartment of Ophthalmology and Biomedical Engineering, University of Southern CaliforniaBeckman Laser Institute, University of California, IrvineBeckman Laser Institute, University of California, IrvineBeckman Laser Institute, University of California, IrvineBeckman Laser Institute, University of California, IrvineDepartment of Ophthalmology and Biomedical Engineering, University of Southern CaliforniaBeckman Laser Institute, University of California, IrvineAbstract Photo-mediated Ultrasound Therapy (PUT), as a new anti-vascular technique, can promote cavitation activity to selectively destruct blood vessels with a significantly lower amount of energy when compared to energy level required by other laser and ultrasound treatment therapies individually. Here, we report the development of a high speed PUT system based on a 50-kHz pulsed laser to achieve faster treatment, decreasing the treatment time by a factor of 20. Furthermore, we integrated it with optical coherence tomography angiography (OCTA) for real time monitoring. The feasibility of the proposed OCTA-guided PUT was validated through in vivo rabbit experiments. The addition of OCTA to PUT allows for quantitative prescreening and real time monitoring of treatment response, thereby enabling implementation of individualized treatment strategies.https://doi.org/10.1038/s41598-022-23188-8 |
| spellingShingle | Yan Li Yuchen Song Runze Li Wangcun Jia Fengyi Zhang Xiaoming Hu Lidek Chou Qifa Zhou Zhongping Chen High speed photo-mediated ultrasound therapy integrated with OCTA Scientific Reports |
| title | High speed photo-mediated ultrasound therapy integrated with OCTA |
| title_full | High speed photo-mediated ultrasound therapy integrated with OCTA |
| title_fullStr | High speed photo-mediated ultrasound therapy integrated with OCTA |
| title_full_unstemmed | High speed photo-mediated ultrasound therapy integrated with OCTA |
| title_short | High speed photo-mediated ultrasound therapy integrated with OCTA |
| title_sort | high speed photo mediated ultrasound therapy integrated with octa |
| url | https://doi.org/10.1038/s41598-022-23188-8 |
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