Neonatal exposure to hypoxia induces early arterial stiffening via activation of lysyl oxidases

Neonatal exposure to hypoxia induces early arterial stiffening via activation of lysyl oxidases

Abstract Hypoxia in the neonatal period is associated with early manifestations of adverse cardiovascular health in adulthood including higher risk of hypertension and atherosclerosis. We hypothesize that this occurs due to activation of lysyl oxidases (LOXs) and the remodeling of the large conduit...

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Bibliographic Details
Main Authors: Jochen Steppan, Kavitha Nandakumar, Huilei Wang, Rosie Jang, Logan Smith, Sara Kang, William Savage, Maria Bauer, Rira Choi, Travis Brady, Bulouere Princess Wodu, Susanna Scafidi, Joseph Scafidi, Lakshmi Santhanam
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Physiological Reports
Subjects:
arterial aging
lysyl oxidase
matrix remodeling
neonatal hypoxia
Online Access:https://doi.org/10.14814/phy2.15656

Internet

https://doi.org/10.14814/phy2.15656

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