Tamoxifen Blocks the Development of Motivational Features of an Addiction-Like Phenotype in Female Rats

Tamoxifen Blocks the Development of Motivational Features of an Addiction-Like Phenotype in Female Rats

Women become addicted sooner after initiating cocaine use as compared to men. Preclinical studies reveal a similar vulnerability in females, with findings from ovariectomized rats suggesting that estradiol mediates the enhanced vulnerability. However, since ovariectomy depletes not only estradiol, b...

Full description

Bibliographic Details
Main Authors: Anousheh Bakhti-Suroosh, Tanseli Nesil, Wendy J. Lynch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
cocaine
estradiol
extended access
self-administration
sex differences
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00253/full

Internet

https://www.frontiersin.org/article/10.3389/fnbeh.2019.00253/full

Similar Items