DNA Cytometry of Immunocompetent Cells of Biomodels under Conditions of Immunization by S-Complex Preparations of Different Tularemia Microbe Subspecies
The effect of S-complex preparations of tularemia microbe upon apoptosis and proliferative activity of cells of central (thymus) and peripheral (spleen) organs of immune system has been studied in dynamics on the outbred white mice model. S-complex preparations were isolated from vaccine strain 15 N...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2011-02-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/593 |
| _version_ | 1797220956899377152 |
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| author | E. A. Smol'kova T. N. Shchukovskaya A. L. Kravtsov E. M. Kuznetsova O. A. Volokh A. K. Nikiforov |
| author_facet | E. A. Smol'kova T. N. Shchukovskaya A. L. Kravtsov E. M. Kuznetsova O. A. Volokh A. K. Nikiforov |
| author_sort | E. A. Smol'kova |
| collection | DOAJ |
| description | The effect of S-complex preparations of tularemia microbe upon apoptosis and proliferative activity of cells of central (thymus) and peripheral (spleen) organs of immune system has been studied in dynamics on the outbred white mice model. S-complex preparations were isolated from vaccine strain 15 NIIEG of holarctica subspecies, virulent strain 503 of the same subspecies, strain Acole of nearctica subspecies and strain A 179 of mediasiatica subspecies. The ratio of cells being at different stages of cell cycle was shown to vary in different periods of time after immunization with the studied preparations. That can be associated with the structure of preparations depending on the source they were obtained from. All preparations demonstrated the lack of harmful effect upon genetic apparatus of white mice' immune cells. The application of the present antigenic complex in the construction of chemical vaccines of new generation is thought to be promising. |
| first_indexed | 2024-03-08T13:44:40Z |
| format | Article |
| id | doaj.art-9feba06bceda4eeda72230c5c5743738 |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:57:47Z |
| publishDate | 2011-02-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-9feba06bceda4eeda72230c5c57437382024-04-05T16:47:06ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2011-02-0101(107)747610.21055/0370-1069-2011-1(107)-74-76577DNA Cytometry of Immunocompetent Cells of Biomodels under Conditions of Immunization by S-Complex Preparations of Different Tularemia Microbe SubspeciesE. A. Smol'kova0T. N. Shchukovskaya1A. L. Kravtsov2E. M. Kuznetsova3O. A. Volokh4A. K. Nikiforov5Russian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeThe effect of S-complex preparations of tularemia microbe upon apoptosis and proliferative activity of cells of central (thymus) and peripheral (spleen) organs of immune system has been studied in dynamics on the outbred white mice model. S-complex preparations were isolated from vaccine strain 15 NIIEG of holarctica subspecies, virulent strain 503 of the same subspecies, strain Acole of nearctica subspecies and strain A 179 of mediasiatica subspecies. The ratio of cells being at different stages of cell cycle was shown to vary in different periods of time after immunization with the studied preparations. That can be associated with the structure of preparations depending on the source they were obtained from. All preparations demonstrated the lack of harmful effect upon genetic apparatus of white mice' immune cells. The application of the present antigenic complex in the construction of chemical vaccines of new generation is thought to be promising.https://journal.microbe.ru/jour/article/view/593<i>francisella tularensis</i>antigensimmunocompetent cellscytometry |
| spellingShingle | E. A. Smol'kova T. N. Shchukovskaya A. L. Kravtsov E. M. Kuznetsova O. A. Volokh A. K. Nikiforov DNA Cytometry of Immunocompetent Cells of Biomodels under Conditions of Immunization by S-Complex Preparations of Different Tularemia Microbe Subspecies Проблемы особо опасных инфекций <i>francisella tularensis</i> antigens immunocompetent cells cytometry |
| title | DNA Cytometry of Immunocompetent Cells of Biomodels under Conditions of Immunization by S-Complex Preparations of Different Tularemia Microbe Subspecies |
| title_full | DNA Cytometry of Immunocompetent Cells of Biomodels under Conditions of Immunization by S-Complex Preparations of Different Tularemia Microbe Subspecies |
| title_fullStr | DNA Cytometry of Immunocompetent Cells of Biomodels under Conditions of Immunization by S-Complex Preparations of Different Tularemia Microbe Subspecies |
| title_full_unstemmed | DNA Cytometry of Immunocompetent Cells of Biomodels under Conditions of Immunization by S-Complex Preparations of Different Tularemia Microbe Subspecies |
| title_short | DNA Cytometry of Immunocompetent Cells of Biomodels under Conditions of Immunization by S-Complex Preparations of Different Tularemia Microbe Subspecies |
| title_sort | dna cytometry of immunocompetent cells of biomodels under conditions of immunization by s complex preparations of different tularemia microbe subspecies |
| topic | <i>francisella tularensis</i> antigens immunocompetent cells cytometry |
| url | https://journal.microbe.ru/jour/article/view/593 |
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