Thyroid Autoimmunity and Gluten-Sensitive Enteropathy in Children with Type 1 Diabetes Mellitus
Introduction: To determine the seroprevalence of autoimmune thyroiditis and gluten-sensitive enteropathy (GSE) in patients with type 1 diabetes mellitus (T1DM) and to emphasize the importance of early diagnosis. Patients and Methods: Fifty-five children and adolescents (age ranged 3-18 years) w...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2012-06-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: | http://www.hasekidergisi.com/article_4657/Thyroid-Autoimmunity-And-Gluten-sensitive-Enteropathy-In-Children-With-Type-1-Diabetes-Mellitus |
| Summary: | Introduction: To determine the seroprevalence of autoimmune
thyroiditis and gluten-sensitive enteropathy (GSE) in patients with
type 1 diabetes mellitus (T1DM) and to emphasize the importance
of early diagnosis.
Patients and Methods: Fifty-five children and adolescents (age
ranged 3-18 years) with T1DM were included in the study. Hemoglobin
A1c (HbA1c), free T3 (fT3), free T4 (fT4), thyroid stimulating hormone
(TSH), anti-tiroglobulin (anti-TG), anti-thyroid peroxidase (anti-TPO),
anti-gliadin IgA and IgG, and anti-endomisyum IgA antibody (antiEMA)
were investigated.
Results: Eight of our cases (14.5%) were positive for anti-TPO, 9/55
(16.3%) for anti-TG, 8/55 (14.5%) for anti-EMA, 8/55 (14.5%) for
anti-gliadin IgA, and 5/55 (9.0%) for anti-gliadin IgG. None of these
antibodies were detected in healthy controls. In eight patients, who
had positive anti-TPO and anti-TG, thyroid ultrasound results
confirmed thyroiditis. Anti-EMA and anti-gliadin IgA were positive in
five patients. Four of them were diagnosed with GSE.
Conclusion: In patients with T1DM, the seroprevalences of
autoimmune thyroiditis and GSE were higher than that in healthy
controls. Therefore, regardless of the symptoms of patients,
autoimmune thyroiditis and GSE should be investigated in all patients
with T1DM. Thus, the most rapid and meaningful method is to
investigate the presence of autoantibodies using serological tests.
(The Me di cal Bul le tin of Ha se ki 2012; 50: 39-42) |
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| ISSN: | 1302-0072 2147-2688 |