The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article
Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical ther...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Gadjah Mada, Yogyakarta
2021-06-01
|
| Series: | Indonesian Journal of Biotechnology |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijbiotech/article/view/63318 |
| _version_ | 1811171014402375680 |
|---|---|
| author | Romaniyanto Romaniyanto Cita Rosita Sigit Prakoeswa Damayanti Tinduh Hari Basuki Notobroto Fedik Abdul Rantam Dwikora Novembri Utomo Heri Suroto Ferdiansyah Ferdiansyah |
| author_facet | Romaniyanto Romaniyanto Cita Rosita Sigit Prakoeswa Damayanti Tinduh Hari Basuki Notobroto Fedik Abdul Rantam Dwikora Novembri Utomo Heri Suroto Ferdiansyah Ferdiansyah |
| author_sort | Romaniyanto Romaniyanto |
| collection | DOAJ |
| description | Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc. |
| first_indexed | 2024-04-10T17:06:27Z |
| format | Article |
| id | doaj.art-9ff3750e634a47509654fb94a7051459 |
| institution | Directory Open Access Journal |
| issn | 0853-8654 2089-2241 |
| language | English |
| last_indexed | 2024-04-10T17:06:27Z |
| publishDate | 2021-06-01 |
| publisher | Universitas Gadjah Mada, Yogyakarta |
| record_format | Article |
| series | Indonesian Journal of Biotechnology |
| spelling | doaj.art-9ff3750e634a47509654fb94a70514592023-02-06T03:00:10ZengUniversitas Gadjah Mada, YogyakartaIndonesian Journal of Biotechnology0853-86542089-22412021-06-01262617510.22146/ijbiotech.6331830143The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review articleRomaniyanto Romaniyanto0Cita Rosita Sigit Prakoeswa1Damayanti Tinduh2Hari Basuki Notobroto3Fedik Abdul Rantam4Dwikora Novembri Utomo5Heri Suroto6Ferdiansyah Ferdiansyah7Doctoral Program, Faculty of Medicine, Airlangga University, Surabaya, Jawa Timur 60132; Department of Orthopedic and Traumatology, Faculty of Medicine, Prof. Dr. R. Soeharso Orthopaedic Hospital, Universitas Sebelas Maret, Surakarta, Jawa Tengah 57126Department of Dermatology and Venereology, Faculty of Medicine, Airlangga University, Surabaya, Jawa Timur 60132; Dr. Soetomo General Academic Hospital, Surabaya, Jawa Timur 60286Dr. Soetomo General Academic Hospital, Surabaya, Jawa Timur 60286; Dr. Soetomo General Academic Hospital, Surabaya, Jawa Timur 60286Dr. Soetomo General Academic Hospital, Surabaya, Jawa Timur 60286Dr. Soetomo General Academic Hospital, Surabaya, Jawa Timur 60286Dr. Soetomo General Academic Hospital, Surabaya, Jawa Timur 60286; Department of Orthopedic and Traumatology, Faculty of Medicine, Faculty of Medicine, Airlangga University, Surabaya, Jawa Timur 60132Dr. Soetomo General Academic Hospital, Surabaya, Jawa Timur 60286; Department of Orthopedic and Traumatology, Faculty of Medicine, Faculty of Medicine, Airlangga University, Surabaya, Jawa Timur 60132Dr. Soetomo General Academic Hospital, Surabaya, Jawa Timur 60286; Department of Orthopedic and Traumatology, Faculty of Medicine, Faculty of Medicine, Airlangga University, Surabaya, Jawa Timur 60132Low back pain is a crucial public health problem that is commonly associated with intervertebral disc de‐ generation and has vast socio‐economic impact worldwide. Current treatments for disc degeneration are conservative, non‐surgical, or surgical interventions, and there is no current clinical therapy aimed at directly reversing the degeneration. Given the limited capacity of intervertebral disc (IVD) cells to self‐repair, treatment aiming to regenerate IVDs is a topic of interest and mesenchymal stem cells (MSCs) have been identified as having potential in this regeneration. Recent studies have revealed that the benefits of MSC therapy could result from the molecules the cells secrete and that play principal roles in regulating essential biologic processes, rather than from the implanted cells themselves. Therefore, the objective of this study is to review the potential use of the MSC secretome to regenerate IVDs. Current evidence shows that the secretome may regenerate IVDs by modulating the gene expressions of nucleus pulposus cells (upregulation of keratin 19 and downregulation of matrix metalloproteinase 12 and matrix Gla protein) and stimulating IVD progenitor cells to repair the degenerated disc.https://jurnal.ugm.ac.id/ijbiotech/article/view/63318intervertebral disc degenerationlow back painmesenchymal stem cellsregenerative propertiessecretome |
| spellingShingle | Romaniyanto Romaniyanto Cita Rosita Sigit Prakoeswa Damayanti Tinduh Hari Basuki Notobroto Fedik Abdul Rantam Dwikora Novembri Utomo Heri Suroto Ferdiansyah Ferdiansyah The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article Indonesian Journal of Biotechnology intervertebral disc degeneration low back pain mesenchymal stem cells regenerative properties secretome |
| title | The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article |
| title_full | The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article |
| title_fullStr | The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article |
| title_full_unstemmed | The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article |
| title_short | The potential of mesenchymal stem‐cell secretome for regeneration of intervertebral disc: A review article |
| title_sort | potential of mesenchymal stem cell secretome for regeneration of intervertebral disc a review article |
| topic | intervertebral disc degeneration low back pain mesenchymal stem cells regenerative properties secretome |
| url | https://jurnal.ugm.ac.id/ijbiotech/article/view/63318 |
| work_keys_str_mv | AT romaniyantoromaniyanto thepotentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT citarositasigitprakoeswa thepotentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT damayantitinduh thepotentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT haribasukinotobroto thepotentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT fedikabdulrantam thepotentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT dwikoranovembriutomo thepotentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT herisuroto thepotentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT ferdiansyahferdiansyah thepotentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT romaniyantoromaniyanto potentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT citarositasigitprakoeswa potentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT damayantitinduh potentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT haribasukinotobroto potentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT fedikabdulrantam potentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT dwikoranovembriutomo potentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT herisuroto potentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle AT ferdiansyahferdiansyah potentialofmesenchymalstemcellsecretomeforregenerationofintervertebraldiscareviewarticle |