Proteomic Phenotyping of Stimulated Müller Cells Uncovers Profound Pro-Inflammatory Signaling and Antigen-Presenting Capacity

Proteomic Phenotyping of Stimulated Müller Cells Uncovers Profound Pro-Inflammatory Signaling and Antigen-Presenting Capacity

Müller cells are the main macroglial cells of the retina exerting a wealth of functions to maintain retinal homoeostasis. Upon pathological changes in the retina, they become gliotic with both protective and detrimental consequences. Accumulating data also provide evidence for a pivotal role of Müll...

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Bibliographic Details
Main Authors: Adrian Schmalen, Lea Lorenz, Antje Grosche, Diana Pauly, Cornelia A. Deeg, Stefanie M. Hauck
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
Müller cells
atypical antigen-presenting cell
immune response
diabetic retinopathy
oxidative phosphorylation
complement system
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.771571/full

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