Quantitative methods in the analysis of clozapine in human matrices – A scoping review
Clozapine (CLZ) has retained its clinical utility in the management of schizophrenia despite the discovery of novel antipsychotics, as it possesses unique efficacy in the setting of treatment resistant schizophrenia while causing minimal extrapyramidal symptoms. However, these benefits are offset by...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2024-03-01
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| Series: | Reviews in Analytical Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/revac-2023-0066 |
| _version_ | 1797246610685558784 |
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| author | Lim Jia Le Rajagopal Mogana Akowuah Gabriel Akyirem Keshavarzi Fazlollah Alakhali Khaled Mohammed Ahmed |
| author_facet | Lim Jia Le Rajagopal Mogana Akowuah Gabriel Akyirem Keshavarzi Fazlollah Alakhali Khaled Mohammed Ahmed |
| author_sort | Lim Jia Le |
| collection | DOAJ |
| description | Clozapine (CLZ) has retained its clinical utility in the management of schizophrenia despite the discovery of novel antipsychotics, as it possesses unique efficacy in the setting of treatment resistant schizophrenia while causing minimal extrapyramidal symptoms. However, these benefits are offset by the risk of agranulocytosis and other side effects, and therapeutic drug monitoring (TDM) is routinely recommended for patients undergoing treatment with CLZ. A multitude of approaches for the quantification of CLZ have been developed for different settings such as TDM, quality control of pharmaceutical dosage forms, and toxicology studies. Primarily, these approaches fall under one of three branches of analysis, namely, chromatography, electrochemical analysis, and spectrophotometry. This study provides a scoping review of the recent advances in the methods of quantification for CLZ and highlights the potential utility of novel methods in the field of drug quantification. |
| first_indexed | 2024-04-24T19:45:32Z |
| format | Article |
| id | doaj.art-9ff4990e7d6a4ffc91d65d8166ce7650 |
| institution | Directory Open Access Journal |
| issn | 2191-0189 |
| language | English |
| last_indexed | 2024-04-24T19:45:32Z |
| publishDate | 2024-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Reviews in Analytical Chemistry |
| spelling | doaj.art-9ff4990e7d6a4ffc91d65d8166ce76502024-03-25T07:29:39ZengDe GruyterReviews in Analytical Chemistry2191-01892024-03-01431S687210.1515/revac-2023-0066Quantitative methods in the analysis of clozapine in human matrices – A scoping reviewLim Jia Le0Rajagopal Mogana1Akowuah Gabriel Akyirem2Keshavarzi Fazlollah3Alakhali Khaled Mohammed Ahmed4Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, MalaysiaFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, MalaysiaMalaysia School of Pharmacy, Monash University Malaysia, Selangor, MalaysiaFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, MalaysiaFaculty of Medical Sciences, Pharmacy Department, Thamar University, Dhamar, Republic of YemenClozapine (CLZ) has retained its clinical utility in the management of schizophrenia despite the discovery of novel antipsychotics, as it possesses unique efficacy in the setting of treatment resistant schizophrenia while causing minimal extrapyramidal symptoms. However, these benefits are offset by the risk of agranulocytosis and other side effects, and therapeutic drug monitoring (TDM) is routinely recommended for patients undergoing treatment with CLZ. A multitude of approaches for the quantification of CLZ have been developed for different settings such as TDM, quality control of pharmaceutical dosage forms, and toxicology studies. Primarily, these approaches fall under one of three branches of analysis, namely, chromatography, electrochemical analysis, and spectrophotometry. This study provides a scoping review of the recent advances in the methods of quantification for CLZ and highlights the potential utility of novel methods in the field of drug quantification.https://doi.org/10.1515/revac-2023-0066clozapinescoping reviewanalysisquantificationchromatography |
| spellingShingle | Lim Jia Le Rajagopal Mogana Akowuah Gabriel Akyirem Keshavarzi Fazlollah Alakhali Khaled Mohammed Ahmed Quantitative methods in the analysis of clozapine in human matrices – A scoping review Reviews in Analytical Chemistry clozapine scoping review analysis quantification chromatography |
| title | Quantitative methods in the analysis of clozapine in human matrices – A scoping review |
| title_full | Quantitative methods in the analysis of clozapine in human matrices – A scoping review |
| title_fullStr | Quantitative methods in the analysis of clozapine in human matrices – A scoping review |
| title_full_unstemmed | Quantitative methods in the analysis of clozapine in human matrices – A scoping review |
| title_short | Quantitative methods in the analysis of clozapine in human matrices – A scoping review |
| title_sort | quantitative methods in the analysis of clozapine in human matrices a scoping review |
| topic | clozapine scoping review analysis quantification chromatography |
| url | https://doi.org/10.1515/revac-2023-0066 |
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