Inhibition of HDAC4 Attenuated JNK/c-Jun-Dependent Neuronal Apoptosis and Early Brain Injury Following Subarachnoid Hemorrhage by Transcriptionally Suppressing MKK7

Inhibition of HDAC4 Attenuated JNK/c-Jun-Dependent Neuronal Apoptosis and Early Brain Injury Following Subarachnoid Hemorrhage by Transcriptionally Suppressing MKK7

The c-Jun N-terminal kinase (JNK)/c-Jun cascade-dependent neuronal apoptosis has been identified as a central element for early brain injury (EBI) following subarachnoid hemorrhage (SAH), but the molecular mechanisms underlying this process are still thoroughly undefined to date. In this study, we f...

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Bibliographic Details
Main Authors: Liqiang Wu, Shulian Zeng, Yali Cao, Ziyan Huang, Sisi Liu, Huaidong Peng, Cheng Zhi, Shanshan Ma, Kunhua Hu, Zhongmin Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
MKK7
JNK
c-Jun
HDAC4
neuronal apoptosis
subarachnoid hemorrhage
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00468/full

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