The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life
Perinatal brain injuries, including hippocampal lesions, cause lasting changes in dopamine function in rodents, but it is not known if this occurs in humans. We compared adults who were born very preterm with perinatal brain injury to those born very preterm without perinatal brain injury, and age-m...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/29088 |
| _version_ | 1811180956496691200 |
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| author | Sean Froudist-Walsh Michael AP Bloomfield Mattia Veronese Jasmin Kroll Vyacheslav R Karolis Sameer Jauhar Ilaria Bonoldi Philip K McGuire Shitij Kapur Robin M Murray Chiara Nosarti Oliver Howes |
| author_facet | Sean Froudist-Walsh Michael AP Bloomfield Mattia Veronese Jasmin Kroll Vyacheslav R Karolis Sameer Jauhar Ilaria Bonoldi Philip K McGuire Shitij Kapur Robin M Murray Chiara Nosarti Oliver Howes |
| author_sort | Sean Froudist-Walsh |
| collection | DOAJ |
| description | Perinatal brain injuries, including hippocampal lesions, cause lasting changes in dopamine function in rodents, but it is not known if this occurs in humans. We compared adults who were born very preterm with perinatal brain injury to those born very preterm without perinatal brain injury, and age-matched controls born at full term using [18F]-DOPA PET and structural MRI. Dopamine synthesis capacity was reduced in the perinatal brain injury group relative to those without brain injury (Cohen’s d = 1.36, p=0.02) and the control group (Cohen’s d = 1.07, p=0.01). Hippocampal volume was reduced in the perinatal brain injury group relative to controls (Cohen’s d = 1.17, p=0.01) and was positively correlated with striatal dopamine synthesis capacity (r = 0.344, p=0.03). This is the first evidence in humans linking neonatal hippocampal injury to adult dopamine dysfunction, and provides a potential mechanism linking early life risk factors to adult mental illness. |
| first_indexed | 2024-04-11T09:12:00Z |
| format | Article |
| id | doaj.art-9ff67e0d97fb4ff1bff59270159f0d58 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:12:00Z |
| publishDate | 2017-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-9ff67e0d97fb4ff1bff59270159f0d582022-12-22T04:32:29ZengeLife Sciences Publications LtdeLife2050-084X2017-11-01610.7554/eLife.29088The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult lifeSean Froudist-Walsh0https://orcid.org/0000-0003-4070-067XMichael AP Bloomfield1Mattia Veronese2Jasmin Kroll3Vyacheslav R Karolis4Sameer Jauhar5Ilaria Bonoldi6Philip K McGuire7Shitij Kapur8Robin M Murray9Chiara Nosarti10Oliver Howes11https://orcid.org/0000-0002-2928-1972Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom; MRC Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, United Kingdom; Friedman Brain Institute, Fishberg Department of Neuroscience, Icahn School of Medicine, New York, United StatesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom; MRC Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, United Kingdom; Division of Psychiatry, University College London, London, United Kingdom; Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology, University College London, London, United KingdomDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom; MRC Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom; MRC Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom; Centre for the Developing Brain, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United KingdomDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's Health Partners, King's College London, London, United Kingdom; MRC Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom; Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital, London, United KingdomPerinatal brain injuries, including hippocampal lesions, cause lasting changes in dopamine function in rodents, but it is not known if this occurs in humans. We compared adults who were born very preterm with perinatal brain injury to those born very preterm without perinatal brain injury, and age-matched controls born at full term using [18F]-DOPA PET and structural MRI. Dopamine synthesis capacity was reduced in the perinatal brain injury group relative to those without brain injury (Cohen’s d = 1.36, p=0.02) and the control group (Cohen’s d = 1.07, p=0.01). Hippocampal volume was reduced in the perinatal brain injury group relative to controls (Cohen’s d = 1.17, p=0.01) and was positively correlated with striatal dopamine synthesis capacity (r = 0.344, p=0.03). This is the first evidence in humans linking neonatal hippocampal injury to adult dopamine dysfunction, and provides a potential mechanism linking early life risk factors to adult mental illness.https://elifesciences.org/articles/29088dopamineimagingpretermbrain volumebrain injury |
| spellingShingle | Sean Froudist-Walsh Michael AP Bloomfield Mattia Veronese Jasmin Kroll Vyacheslav R Karolis Sameer Jauhar Ilaria Bonoldi Philip K McGuire Shitij Kapur Robin M Murray Chiara Nosarti Oliver Howes The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life eLife dopamine imaging preterm brain volume brain injury |
| title | The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life |
| title_full | The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life |
| title_fullStr | The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life |
| title_full_unstemmed | The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life |
| title_short | The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life |
| title_sort | effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life |
| topic | dopamine imaging preterm brain volume brain injury |
| url | https://elifesciences.org/articles/29088 |
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