Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review
Abstract Objective This study aimed to systematically review the associations between motor clinical phenotypes in Parkinson's disease (PD) and laryngeal disease symptoms. Laryngeal dysfunctions such as dysphonia and dysphagia are ubiquitous in people with Parkinson's disease (PwPD). Simil...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Laryngoscope Investigative Otolaryngology |
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| Online Access: | https://doi.org/10.1002/lio2.1112 |
| _version_ | 1797738270742806528 |
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| author | Zoe Thijs Matthew Dumican |
| author_facet | Zoe Thijs Matthew Dumican |
| author_sort | Zoe Thijs |
| collection | DOAJ |
| description | Abstract Objective This study aimed to systematically review the associations between motor clinical phenotypes in Parkinson's disease (PD) and laryngeal disease symptoms. Laryngeal dysfunctions such as dysphonia and dysphagia are ubiquitous in people with Parkinson's disease (PwPD). Similar to other disease symptoms, they manifest variably across PwPD. Some of the variability within PD has been explained by clinical phenotypes. However, it is unclear how laryngeal symptoms of PD express themselves across these phenotypes. Methods Five databases were searched (MEDLINE, CINAHL, Web of Science, Embase, Scopus) in May 2022. After the removal of duplicates, all retrieved records were screened. Cohort, case–control, and cross‐sectional studies in English discussing laryngeal symptoms and clinical PD phenotypes were included. Data were extracted, tabulated, and assessed using Moola et al.'s (2021) appraisal tool for systematic reviews of risk and etiology. Results The search retrieved 2370 records, representing 540 PwPD. After the removal of duplicates and screening, eight articles were included for review. The most common phenotype categories were tremor‐dominant and postural‐instability gait disordered (PIGD). Five studies addressed vocal characteristics, while four considered swallowing. Differences and lack of rigor in methodology across studies complicated conclusions, but a tendency for tremor‐dominant phenotypes to present with less severe laryngeal symptoms was found. Conclusion Some minor differences in laryngeal function were found between tremor‐dominant and PIGD phenotypes in PD. However, there is a need for more standardized and high‐quality studies when comparing motor phenotypes for laryngeal function. |
| first_indexed | 2024-03-12T13:41:25Z |
| format | Article |
| id | doaj.art-9ff75ed6e9324bb9b761b1fa2422d67d |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-03-12T13:41:25Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-9ff75ed6e9324bb9b761b1fa2422d67d2023-08-23T18:20:18ZengWileyLaryngoscope Investigative Otolaryngology2378-80382023-08-018497097910.1002/lio2.1112Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic reviewZoe Thijs0Matthew Dumican1Department of Communication Sciences and Disorders Molloy University Rockville Centre New York USADepartment of Speech, Language and Hearing Sciences Western Michigan University Kalamazoo Michigan USAAbstract Objective This study aimed to systematically review the associations between motor clinical phenotypes in Parkinson's disease (PD) and laryngeal disease symptoms. Laryngeal dysfunctions such as dysphonia and dysphagia are ubiquitous in people with Parkinson's disease (PwPD). Similar to other disease symptoms, they manifest variably across PwPD. Some of the variability within PD has been explained by clinical phenotypes. However, it is unclear how laryngeal symptoms of PD express themselves across these phenotypes. Methods Five databases were searched (MEDLINE, CINAHL, Web of Science, Embase, Scopus) in May 2022. After the removal of duplicates, all retrieved records were screened. Cohort, case–control, and cross‐sectional studies in English discussing laryngeal symptoms and clinical PD phenotypes were included. Data were extracted, tabulated, and assessed using Moola et al.'s (2021) appraisal tool for systematic reviews of risk and etiology. Results The search retrieved 2370 records, representing 540 PwPD. After the removal of duplicates and screening, eight articles were included for review. The most common phenotype categories were tremor‐dominant and postural‐instability gait disordered (PIGD). Five studies addressed vocal characteristics, while four considered swallowing. Differences and lack of rigor in methodology across studies complicated conclusions, but a tendency for tremor‐dominant phenotypes to present with less severe laryngeal symptoms was found. Conclusion Some minor differences in laryngeal function were found between tremor‐dominant and PIGD phenotypes in PD. However, there is a need for more standardized and high‐quality studies when comparing motor phenotypes for laryngeal function.https://doi.org/10.1002/lio2.1112dysphagiahypokinetic dysarthrialarynxParkinson's diseasephenotypesvoice |
| spellingShingle | Zoe Thijs Matthew Dumican Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review Laryngoscope Investigative Otolaryngology dysphagia hypokinetic dysarthria larynx Parkinson's disease phenotypes voice |
| title | Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review |
| title_full | Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review |
| title_fullStr | Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review |
| title_full_unstemmed | Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review |
| title_short | Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review |
| title_sort | laryngeal symptoms related to motor phenotypes in parkinson s disease a systematic review |
| topic | dysphagia hypokinetic dysarthria larynx Parkinson's disease phenotypes voice |
| url | https://doi.org/10.1002/lio2.1112 |
| work_keys_str_mv | AT zoethijs laryngealsymptomsrelatedtomotorphenotypesinparkinsonsdiseaseasystematicreview AT matthewdumican laryngealsymptomsrelatedtomotorphenotypesinparkinsonsdiseaseasystematicreview |