Population measles seroprevalence: Heterogeneity by birth-year cohort
Objective: This work sought to estimate population measles seroprevalence and heterogeneity in the antibody concentration distribution that could be explained by the birth-year cohort according to the opportunity of viral and vaccine exposure, applied to data from Medellín, Colombia. Methods: Preval...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Journal of Virus Eradication |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664023000389 |
| _version_ | 1827400961249771520 |
|---|---|
| author | Eduardo Santacruz-Sanmartin Doracelly Hincapié-Palacio Jesús Ochoa Seti Buitrago Marta Ospina |
| author_facet | Eduardo Santacruz-Sanmartin Doracelly Hincapié-Palacio Jesús Ochoa Seti Buitrago Marta Ospina |
| author_sort | Eduardo Santacruz-Sanmartin |
| collection | DOAJ |
| description | Objective: This work sought to estimate population measles seroprevalence and heterogeneity in the antibody concentration distribution that could be explained by the birth-year cohort according to the opportunity of viral and vaccine exposure, applied to data from Medellín, Colombia. Methods: Prevalence of IgG antibodies was analyzed for measles based on a population study with a random sample of 2098 individuals from 6 to 64 years of age. Finite mixture models were used to estimate global seroprevalence and that of three birth-year cohorts (I: born up to 1982; II: 1983–1994; III: born since 1995). Multiple linear regression permitted adjusting the concentration of antibodies by cohort, zone, and sex. Results: Globally, seronegativity was 6.5% (95% CI 4.9– 8.6), seropositivity of 78.4% (95% CI 75.1–81.4), and equivocal of 15.1% (95% CI 12.5–18.1). Two components were found with skewed normal distribution, which reclassified those equivocal as seropositive. Differences were observed by cohort in the geometric mean of antibodies [Cohort I: 1704.6; II: 562.2; III: 802.1 milli-international units per milliliter (mIU/mL] and seronegativity (Cohort I: 4%; II:13.3%; III: 8.9%). Antibody concentration increased by 1.26 mIU/mL in residents in the rural area, while diminishing in individuals from cohort II (by 3.02 mIU/mL) and cohort III (by 2.14 mIU/mL). Conclusion: The younger cohorts (II and III) had a lower antibody concentration (higher seronegativity), indicating the need to monitor periodically seroprevalence and an eventual reestablishment of the transmission in these groups with higher risk of infection. |
| first_indexed | 2024-03-08T20:12:16Z |
| format | Article |
| id | doaj.art-9ff7953492a54615896709b1a9fcbb01 |
| institution | Directory Open Access Journal |
| issn | 2055-6640 |
| language | English |
| last_indexed | 2024-03-08T20:12:16Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj.art-9ff7953492a54615896709b1a9fcbb012023-12-23T05:20:28ZengElsevierJournal of Virus Eradication2055-66402023-12-0194100352Population measles seroprevalence: Heterogeneity by birth-year cohortEduardo Santacruz-Sanmartin0Doracelly Hincapié-Palacio1Jesús Ochoa2Seti Buitrago3Marta Ospina4Epidemiology Research Group in “Héctor Abad Gómez” National Faculty of Public Health at University of Antioquia, St 62 # 52-59, Medellín, Colombia; Corresponding author.Epidemiology Research Group in “Héctor Abad Gómez” National Faculty of Public Health at University of Antioquia, St 62 # 52-59, Medellín, ColombiaEpidemiology Research Group in “Héctor Abad Gómez” National Faculty of Public Health at University of Antioquia, St 62 # 52-59, Medellín, ColombiaDepartmental Laboratory of Public Health- the Sectional Secretariat of Health and Social Protection of Antioquia, St 72 A # 78 B 141, Third Floor, Medellín, ColombiaDepartmental Laboratory of Public Health- the Sectional Secretariat of Health and Social Protection of Antioquia, St 72 A # 78 B 141, Third Floor, Medellín, ColombiaObjective: This work sought to estimate population measles seroprevalence and heterogeneity in the antibody concentration distribution that could be explained by the birth-year cohort according to the opportunity of viral and vaccine exposure, applied to data from Medellín, Colombia. Methods: Prevalence of IgG antibodies was analyzed for measles based on a population study with a random sample of 2098 individuals from 6 to 64 years of age. Finite mixture models were used to estimate global seroprevalence and that of three birth-year cohorts (I: born up to 1982; II: 1983–1994; III: born since 1995). Multiple linear regression permitted adjusting the concentration of antibodies by cohort, zone, and sex. Results: Globally, seronegativity was 6.5% (95% CI 4.9– 8.6), seropositivity of 78.4% (95% CI 75.1–81.4), and equivocal of 15.1% (95% CI 12.5–18.1). Two components were found with skewed normal distribution, which reclassified those equivocal as seropositive. Differences were observed by cohort in the geometric mean of antibodies [Cohort I: 1704.6; II: 562.2; III: 802.1 milli-international units per milliliter (mIU/mL] and seronegativity (Cohort I: 4%; II:13.3%; III: 8.9%). Antibody concentration increased by 1.26 mIU/mL in residents in the rural area, while diminishing in individuals from cohort II (by 3.02 mIU/mL) and cohort III (by 2.14 mIU/mL). Conclusion: The younger cohorts (II and III) had a lower antibody concentration (higher seronegativity), indicating the need to monitor periodically seroprevalence and an eventual reestablishment of the transmission in these groups with higher risk of infection.http://www.sciencedirect.com/science/article/pii/S2055664023000389MeaslesSeroprevalenceFinite mixture modelColombia |
| spellingShingle | Eduardo Santacruz-Sanmartin Doracelly Hincapié-Palacio Jesús Ochoa Seti Buitrago Marta Ospina Population measles seroprevalence: Heterogeneity by birth-year cohort Journal of Virus Eradication Measles Seroprevalence Finite mixture model Colombia |
| title | Population measles seroprevalence: Heterogeneity by birth-year cohort |
| title_full | Population measles seroprevalence: Heterogeneity by birth-year cohort |
| title_fullStr | Population measles seroprevalence: Heterogeneity by birth-year cohort |
| title_full_unstemmed | Population measles seroprevalence: Heterogeneity by birth-year cohort |
| title_short | Population measles seroprevalence: Heterogeneity by birth-year cohort |
| title_sort | population measles seroprevalence heterogeneity by birth year cohort |
| topic | Measles Seroprevalence Finite mixture model Colombia |
| url | http://www.sciencedirect.com/science/article/pii/S2055664023000389 |
| work_keys_str_mv | AT eduardosantacruzsanmartin populationmeaslesseroprevalenceheterogeneitybybirthyearcohort AT doracellyhincapiepalacio populationmeaslesseroprevalenceheterogeneitybybirthyearcohort AT jesusochoa populationmeaslesseroprevalenceheterogeneitybybirthyearcohort AT setibuitrago populationmeaslesseroprevalenceheterogeneitybybirthyearcohort AT martaospina populationmeaslesseroprevalenceheterogeneitybybirthyearcohort |