Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo
During the erythrocyte (RBC) stage of P. falciparum infection variant surface antigens (VSAs) such as PfEMP1s and RIFINs expressed on RBCs are important for infection and evasion of host innate immune system. Here, Chew et al. use a NSG mouse model, which is deficient in B, T and NK cells but retain...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31741-2 |
| _version_ | 1818517649918787584 |
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| author | Marvin Chew Weijian Ye Radoslaw Igor Omelianczyk Charisse Flerida Pasaje Regina Hoo Qingfeng Chen Jacquin C. Niles Jianzhu Chen Peter Preiser |
| author_facet | Marvin Chew Weijian Ye Radoslaw Igor Omelianczyk Charisse Flerida Pasaje Regina Hoo Qingfeng Chen Jacquin C. Niles Jianzhu Chen Peter Preiser |
| author_sort | Marvin Chew |
| collection | DOAJ |
| description | During the erythrocyte (RBC) stage of P. falciparum infection variant surface antigens (VSAs) such as PfEMP1s and RIFINs expressed on RBCs are important for infection and evasion of host innate immune system. Here, Chew et al. use a NSG mouse model, which is deficient in B, T and NK cells but retains macrophages, to show that PfEMP1 surface expression is required for in vivo adaptation as well as in vitro evasion of macrophage phagocytosis. |
| first_indexed | 2024-12-11T00:59:06Z |
| format | Article |
| id | doaj.art-9ff80ee8ef3d4393a5e27c06c8575028 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T00:59:06Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9ff80ee8ef3d4393a5e27c06c85750282022-12-22T01:26:22ZengNature PortfolioNature Communications2041-17232022-07-0113111210.1038/s41467-022-31741-2Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivoMarvin Chew0Weijian Ye1Radoslaw Igor Omelianczyk2Charisse Flerida Pasaje3Regina Hoo4Qingfeng Chen5Jacquin C. Niles6Jianzhu Chen7Peter Preiser8School of Biological Sciences, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversityDepartment of Biological Engineering, Massachusetts Institute of TechnologySchool of Biological Sciences, Nanyang Technological UniversityHumanized Mouse Unit, Institute of Molecular and Cell Biology, Agency of Science, Technology and ResearchDepartment of Biological Engineering, Massachusetts Institute of TechnologySingapore-MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research GroupSchool of Biological Sciences, Nanyang Technological UniversityDuring the erythrocyte (RBC) stage of P. falciparum infection variant surface antigens (VSAs) such as PfEMP1s and RIFINs expressed on RBCs are important for infection and evasion of host innate immune system. Here, Chew et al. use a NSG mouse model, which is deficient in B, T and NK cells but retains macrophages, to show that PfEMP1 surface expression is required for in vivo adaptation as well as in vitro evasion of macrophage phagocytosis.https://doi.org/10.1038/s41467-022-31741-2 |
| spellingShingle | Marvin Chew Weijian Ye Radoslaw Igor Omelianczyk Charisse Flerida Pasaje Regina Hoo Qingfeng Chen Jacquin C. Niles Jianzhu Chen Peter Preiser Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo Nature Communications |
| title | Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo |
| title_full | Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo |
| title_fullStr | Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo |
| title_full_unstemmed | Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo |
| title_short | Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo |
| title_sort | selective expression of variant surface antigens enables plasmodium falciparum to evade immune clearance in vivo |
| url | https://doi.org/10.1038/s41467-022-31741-2 |
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