Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses
Covaxin/BBV152 is a whole virion inactivated SARS-CoV-2 vaccine. The effect of prime-boost vaccination with Covaxin on systemic immune responses is not known. We investigated the effect of Covaxin on the plasma levels of a wide panel of cytokines and chemokines at baseline (M0) and at months 1 (M1),...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.752397/full |
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| author | Nathella Pavan Kumar V. V. Banurekha Girish Kumar C. P. Arul Nancy C. Padmapriyadarsini A. Stella Mary K. R. Uma Devi Manoj Murhekar Subash Babu |
| author_facet | Nathella Pavan Kumar V. V. Banurekha Girish Kumar C. P. Arul Nancy C. Padmapriyadarsini A. Stella Mary K. R. Uma Devi Manoj Murhekar Subash Babu |
| author_sort | Nathella Pavan Kumar |
| collection | DOAJ |
| description | Covaxin/BBV152 is a whole virion inactivated SARS-CoV-2 vaccine. The effect of prime-boost vaccination with Covaxin on systemic immune responses is not known. We investigated the effect of Covaxin on the plasma levels of a wide panel of cytokines and chemokines at baseline (M0) and at months 1 (M1), 2 (M2) and 3 (M3) following prime-boost vaccination in healthy volunteers. Our results demonstrate that Covaxin induces enhanced plasma levels of Type 1 cytokines (IFNγ, IL-2, TNFα), Type 2/regulatory cytokines (IL-4, IL-5, IL-10 and IL-13), Type 17 cytokine (IL-17A), other pro-inflammatory cytokines (IL-6, IL-12, IL-1α, IL-1β) and other cytokines (IL-3 and IL-7) but diminished plasma levels of IL-25, IL-33, GM-CSF and Type 1 IFNs. Covaxin also induced enhanced plasma levels of CC chemokine (CCL4) and CXC chemokines (CXCL1, CXCL2 and CX3CL1) but diminished levels of CXCL10. Covaxin vaccination induces enhanced cytokine and chemokine responses as early as month 1, following prime-boost vaccination, indicating robust activation of innate and adaptive immune responses in vaccine recipients. |
| first_indexed | 2024-12-22T09:01:53Z |
| format | Article |
| id | doaj.art-9ff851b346ce47b0a7017c1786ad5e55 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T09:01:53Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9ff851b346ce47b0a7017c1786ad5e552022-12-21T18:31:42ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-10-011210.3389/fimmu.2021.752397752397Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine ResponsesNathella Pavan Kumar0V. V. Banurekha1Girish Kumar C. P.2Arul Nancy3C. Padmapriyadarsini4A. Stella Mary5K. R. Uma Devi6Manoj Murhekar7Subash Babu8Indian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, IndiaIndian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, IndiaIndian Council of Medical Research-National Institute of Epidemiology, Chennai, IndiaIndian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, IndiaIndian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, IndiaIndian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, IndiaIndian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, IndiaIndian Council of Medical Research-National Institute of Epidemiology, Chennai, IndiaIndian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis, Chennai, IndiaCovaxin/BBV152 is a whole virion inactivated SARS-CoV-2 vaccine. The effect of prime-boost vaccination with Covaxin on systemic immune responses is not known. We investigated the effect of Covaxin on the plasma levels of a wide panel of cytokines and chemokines at baseline (M0) and at months 1 (M1), 2 (M2) and 3 (M3) following prime-boost vaccination in healthy volunteers. Our results demonstrate that Covaxin induces enhanced plasma levels of Type 1 cytokines (IFNγ, IL-2, TNFα), Type 2/regulatory cytokines (IL-4, IL-5, IL-10 and IL-13), Type 17 cytokine (IL-17A), other pro-inflammatory cytokines (IL-6, IL-12, IL-1α, IL-1β) and other cytokines (IL-3 and IL-7) but diminished plasma levels of IL-25, IL-33, GM-CSF and Type 1 IFNs. Covaxin also induced enhanced plasma levels of CC chemokine (CCL4) and CXC chemokines (CXCL1, CXCL2 and CX3CL1) but diminished levels of CXCL10. Covaxin vaccination induces enhanced cytokine and chemokine responses as early as month 1, following prime-boost vaccination, indicating robust activation of innate and adaptive immune responses in vaccine recipients.https://www.frontiersin.org/articles/10.3389/fimmu.2021.752397/fullcovaxincytokineschemokinesSARS-CoV-2COVID-19vaccination |
| spellingShingle | Nathella Pavan Kumar V. V. Banurekha Girish Kumar C. P. Arul Nancy C. Padmapriyadarsini A. Stella Mary K. R. Uma Devi Manoj Murhekar Subash Babu Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses Frontiers in Immunology covaxin cytokines chemokines SARS-CoV-2 COVID-19 vaccination |
| title | Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses |
| title_full | Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses |
| title_fullStr | Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses |
| title_full_unstemmed | Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses |
| title_short | Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses |
| title_sort | prime boost vaccination with covaxin bbv152 induces heightened systemic cytokine and chemokine responses |
| topic | covaxin cytokines chemokines SARS-CoV-2 COVID-19 vaccination |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.752397/full |
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