Requirement of Histone Deacetylase 6 for Interleukin-6 Induced Epithelial-Mesenchymal Transition, Proliferation, and Migration of Peritoneal Mesothelial Cells

Requirement of Histone Deacetylase 6 for Interleukin-6 Induced Epithelial-Mesenchymal Transition, Proliferation, and Migration of Peritoneal Mesothelial Cells

Aims: Influenced by microenvironment, human peritoneal mesothelial cells (HPMCs) acquired fibrotic phenotype, which was identified as the protagonist for peritoneal fibrosis. In this study, we examined the role of histone deacetylase 6 (HDAC6) for interleukin-6 (IL-6) induced epithelial-mesenchymal...

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Bibliographic Details
Main Authors: Yingfeng Shi, Min Tao, Jun Ni, Lunxian Tang, Feng Liu, Hui Chen, Xiaoyan Ma, Yan Hu, Xun Zhou, Andong Qiu, Shougang Zhuang, Na Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
histone deacetylase 6
interleukin-6
epithelial-mesenchymal transition
proliferation
migration
peritoneal mesothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.722638/full

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