The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized Children
Malnutrition in hospitalized children represents a significant burden with occasionally detrimental consequences. In this retrospective analysis of pediatric patients aged one to 16 years old, who were hospitalized in the children’s cantonal hospital of Aarau, Switzerland, we investigated the utiliz...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/9/1378 |
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| author | Spyridoula Gysi Michael Doulberis Corinne Légeret Henrik Köhler |
| author_facet | Spyridoula Gysi Michael Doulberis Corinne Légeret Henrik Köhler |
| author_sort | Spyridoula Gysi |
| collection | DOAJ |
| description | Malnutrition in hospitalized children represents a significant burden with occasionally detrimental consequences. In this retrospective analysis of pediatric patients aged one to 16 years old, who were hospitalized in the children’s cantonal hospital of Aarau, Switzerland, we investigated the utilization of PYMS (Pediatric Yorkhill Malnutrition Score) as a routine screening tool for malnutrition in pediatric inpatients. Additionally, we explored the correlation between PYMS and NLR (neutrophil–lymphocyte ratio) and PLR (platelet–lymphocyte ratio), which are two novel biomarkers. Various parameters were analyzed from the medical records of the patients. Most of the sample (n = 211, 77.3%) was characterized by a low PYMS of 0–1 point. Greater NLR and PLR values were significantly associated with greater PYMS (<i>p</i> = 0.030 and <i>p</i> = 0.004, respectively). ROC (receiver operating characteristic curves) analysis revealed that PLR had a significant predictive ability for having PYMS > 1 (AUC = 0.59; 95% CI: 0.51–0.68; <i>p</i> = 0.024). The optimal cut-off was 151 with sensitivity of 51.6% (95% CI: 38.6–64.5%) and specificity of 67.3% (95% CI: 60.5–73.6%). Furthermore, 37% of the children (n = 101) yielded a PLR over 151. Our results support a promising value of PLR as a predictive marker for moderate to severe malnutrition in hospitalized children. |
| first_indexed | 2024-03-10T00:23:58Z |
| format | Article |
| id | doaj.art-9ffb657e5012452c99125b6801568399 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T00:23:58Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-9ffb657e5012452c99125b68015683992023-11-23T15:38:05ZengMDPI AGChildren2227-90672022-09-0199137810.3390/children9091378The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized ChildrenSpyridoula Gysi0Michael Doulberis1Corinne Légeret2Henrik Köhler3Children’s Hospital of Aarau, 5001 Aarau, SwitzerlandDivision of Gastroenterology and Hepatology, Medical University Department, Cantonal Hospital of Aarau, 5001 Aarau, SwitzerlandMedical Faculty, University of Basel, 4001 Basel, SwitzerlandChildren’s Hospital of Aarau, 5001 Aarau, SwitzerlandMalnutrition in hospitalized children represents a significant burden with occasionally detrimental consequences. In this retrospective analysis of pediatric patients aged one to 16 years old, who were hospitalized in the children’s cantonal hospital of Aarau, Switzerland, we investigated the utilization of PYMS (Pediatric Yorkhill Malnutrition Score) as a routine screening tool for malnutrition in pediatric inpatients. Additionally, we explored the correlation between PYMS and NLR (neutrophil–lymphocyte ratio) and PLR (platelet–lymphocyte ratio), which are two novel biomarkers. Various parameters were analyzed from the medical records of the patients. Most of the sample (n = 211, 77.3%) was characterized by a low PYMS of 0–1 point. Greater NLR and PLR values were significantly associated with greater PYMS (<i>p</i> = 0.030 and <i>p</i> = 0.004, respectively). ROC (receiver operating characteristic curves) analysis revealed that PLR had a significant predictive ability for having PYMS > 1 (AUC = 0.59; 95% CI: 0.51–0.68; <i>p</i> = 0.024). The optimal cut-off was 151 with sensitivity of 51.6% (95% CI: 38.6–64.5%) and specificity of 67.3% (95% CI: 60.5–73.6%). Furthermore, 37% of the children (n = 101) yielded a PLR over 151. Our results support a promising value of PLR as a predictive marker for moderate to severe malnutrition in hospitalized children.https://www.mdpi.com/2227-9067/9/9/1378malnutritionpediatricPYMSneutrophillymphocyteplatelet |
| spellingShingle | Spyridoula Gysi Michael Doulberis Corinne Légeret Henrik Köhler The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized Children Children malnutrition pediatric PYMS neutrophil lymphocyte platelet |
| title | The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized Children |
| title_full | The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized Children |
| title_fullStr | The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized Children |
| title_full_unstemmed | The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized Children |
| title_short | The Role of the Pediatric Yorkhill Malnutrition Score (PYMS), Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Malnutrition Prediction of Hospitalized Children |
| title_sort | role of the pediatric yorkhill malnutrition score pyms neutrophil to lymphocyte and platelet to lymphocyte ratios in malnutrition prediction of hospitalized children |
| topic | malnutrition pediatric PYMS neutrophil lymphocyte platelet |
| url | https://www.mdpi.com/2227-9067/9/9/1378 |
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