Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents
Alcohol and cannabis are two of the most commonly used substances by adolescents and are associated with adverse medical and psychiatric outcomes. These adverse psychiatric outcomes may reflect the negative impact of alcohol and/or cannabis abuse on neural systems mediating reward and/or error detec...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-04-01
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| Series: | Developmental Cognitive Neuroscience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929318301300 |
| _version_ | 1818041803872403456 |
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| author | Joseph Aloi Harma Meffert Stuart F. White Karina S. Blair Soonjo Hwang Patrick M. Tyler Laura C. Thornton Kathleen I. Crum Kathryn O. Adams Abraham D. Killanin Francesca Filbey Kayla Pope R. James R. Blair |
| author_facet | Joseph Aloi Harma Meffert Stuart F. White Karina S. Blair Soonjo Hwang Patrick M. Tyler Laura C. Thornton Kathleen I. Crum Kathryn O. Adams Abraham D. Killanin Francesca Filbey Kayla Pope R. James R. Blair |
| author_sort | Joseph Aloi |
| collection | DOAJ |
| description | Alcohol and cannabis are two of the most commonly used substances by adolescents and are associated with adverse medical and psychiatric outcomes. These adverse psychiatric outcomes may reflect the negative impact of alcohol and/or cannabis abuse on neural systems mediating reward and/or error detection. However, work indicative of this has mostly been conducted in adults with Alcohol and/or Cannabis Use Disorder (i.e., AUD and CUD), with relatively little work in adolescent patients. Furthermore, of the work that has been conducted in adolescents, groups were based on categorical diagnoses of AUD and/or CUD, so the relationship between AUD and/or CUD symptom severity in adolescents and neural dysfunction is unclear. We used a Monetary Incentive Delay (MID) task to examine the relationship between AUDIT and/or CUDIT scores and functional integrity of neuro-circuitries mediating reward processing and error detection within 150 adolescents. Our findings indicate that AUDIT score is negatively related to activity in reward processing neuro-circuitry in adolescents. However, CUDIT score is negatively related to activity in brain regions involved in error detection. Each of these relationships reflected a medium effect size (Partial-η2 0.09-0.14). These data suggest differential impacts of AUD and CUD on reward versus error detection neuro-circuitries within the adolescent brain. Keywords: Adolescent, Alcohol use disorder, Anterior cingulate cortex, Cannabis use disorder, fMRI, Striatum |
| first_indexed | 2024-12-10T08:36:14Z |
| format | Article |
| id | doaj.art-9ffcd1448fdf42ae95782e6c17213082 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-12-10T08:36:14Z |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-9ffcd1448fdf42ae95782e6c172130822022-12-22T01:55:58ZengElsevierDevelopmental Cognitive Neuroscience1878-92932019-04-0136Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescentsJoseph Aloi0Harma Meffert1Stuart F. White2Karina S. Blair3Soonjo Hwang4Patrick M. Tyler5Laura C. Thornton6Kathleen I. Crum7Kathryn O. Adams8Abraham D. Killanin9Francesca Filbey10Kayla Pope11R. James R. Blair12Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesDepartment of Psychiatry, University of Nebraska Medical Center, Omaha, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United StatesCenter for BrainHealth, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States; Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE, United States; Department of Psychiatry, Creighton University, Omaha, NE, United StatesCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, United States; Corresponding author at: Center for Neurobehavioral Research, Boys Town National Research Hospital, 14100 Crawford Street, Boys Town, NE, 68010, United States.Alcohol and cannabis are two of the most commonly used substances by adolescents and are associated with adverse medical and psychiatric outcomes. These adverse psychiatric outcomes may reflect the negative impact of alcohol and/or cannabis abuse on neural systems mediating reward and/or error detection. However, work indicative of this has mostly been conducted in adults with Alcohol and/or Cannabis Use Disorder (i.e., AUD and CUD), with relatively little work in adolescent patients. Furthermore, of the work that has been conducted in adolescents, groups were based on categorical diagnoses of AUD and/or CUD, so the relationship between AUD and/or CUD symptom severity in adolescents and neural dysfunction is unclear. We used a Monetary Incentive Delay (MID) task to examine the relationship between AUDIT and/or CUDIT scores and functional integrity of neuro-circuitries mediating reward processing and error detection within 150 adolescents. Our findings indicate that AUDIT score is negatively related to activity in reward processing neuro-circuitry in adolescents. However, CUDIT score is negatively related to activity in brain regions involved in error detection. Each of these relationships reflected a medium effect size (Partial-η2 0.09-0.14). These data suggest differential impacts of AUD and CUD on reward versus error detection neuro-circuitries within the adolescent brain. Keywords: Adolescent, Alcohol use disorder, Anterior cingulate cortex, Cannabis use disorder, fMRI, Striatumhttp://www.sciencedirect.com/science/article/pii/S1878929318301300 |
| spellingShingle | Joseph Aloi Harma Meffert Stuart F. White Karina S. Blair Soonjo Hwang Patrick M. Tyler Laura C. Thornton Kathleen I. Crum Kathryn O. Adams Abraham D. Killanin Francesca Filbey Kayla Pope R. James R. Blair Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents Developmental Cognitive Neuroscience |
| title | Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents |
| title_full | Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents |
| title_fullStr | Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents |
| title_full_unstemmed | Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents |
| title_short | Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents |
| title_sort | differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error processing neuro circuitries in adolescents |
| url | http://www.sciencedirect.com/science/article/pii/S1878929318301300 |
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