Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models
Mahajanaka mango, a hybrid cultivar of <i>Mangifera indica</i> Linn., is a highly nutritional fruit that is popularly consumed in Thailand. It has been used in traditional medicine due to its abundance of phytonutrients. The present study aimed to investigate the chemical compositions an...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/22/12216 |
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| author | Narisara Paradee Rattanaporn Janthip Tawat Taesothikul Duangta Kanjanapothi Kornvipa Settakorn Somdet Srichairatanakool Pimpisid Koonyosying |
| author_facet | Narisara Paradee Rattanaporn Janthip Tawat Taesothikul Duangta Kanjanapothi Kornvipa Settakorn Somdet Srichairatanakool Pimpisid Koonyosying |
| author_sort | Narisara Paradee |
| collection | DOAJ |
| description | Mahajanaka mango, a hybrid cultivar of <i>Mangifera indica</i> Linn., is a highly nutritional fruit that is popularly consumed in Thailand. It has been used in traditional medicine due to its abundance of phytonutrients. The present study aimed to investigate the chemical compositions and antioxidant activity of Mahajanaka mango pulp extract (MPE) in vitro. Additionally, we examined its biological activities, including the analgesic, anti-inflammatory, gastroprotective, and hepatoprotective effects of MPE, in murine models. MPE exhibited high levels of phenolic compounds, mangiferin, β-carotene, and vitamin C, and it potentially showed antioxidant properties in an ABTS scavenging assay. The animal results have revealed that oral administration of MPE (1000 mg/kg body weight (BW)) significantly decreased acetic acid-induced writhing responses in mice. Interestingly, local applications of MPE at 1 mg/ear ameliorated ethyl phenylpropiolate (EPP)-induced ear edema, while gavage of MPE at 1000 mg/kg BW significantly decreased carrageenan-induced hind paw edema in rats. MPE can also protect against gastric ulcers induced by stress, hydrochloric acid/ethanol, and indomethacin in rats. Indeed, MPE (250 mg/kg BW) markedly lowered the level of serum alanine aminotransferase activity and hepatic lipid accumulation in rats with CCl<sub>4</sub>- and paracetamol-induced hepatotoxicity. Taken together, the findings suggested that MPE exerts potent antioxidant, analgesic, anti-inflammatory, gastroprotective, and hepatoprotective effects. |
| first_indexed | 2024-03-09T17:03:43Z |
| format | Article |
| id | doaj.art-9ffdb91e24194fc3a4087774b1bbe5dd |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T17:03:43Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-9ffdb91e24194fc3a4087774b1bbe5dd2023-11-24T14:26:41ZengMDPI AGApplied Sciences2076-34172023-11-0113221221610.3390/app132212216Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine ModelsNarisara Paradee0Rattanaporn Janthip1Tawat Taesothikul2Duangta Kanjanapothi3Kornvipa Settakorn4Somdet Srichairatanakool5Pimpisid Koonyosying6Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandFaculty of Pharmacy, Payap University, Chiang Mai 50000, ThailandFaculty of Pharmacy, Payap University, Chiang Mai 50000, ThailandFaculty of Pharmacy, Payap University, Chiang Mai 50000, ThailandDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandMahajanaka mango, a hybrid cultivar of <i>Mangifera indica</i> Linn., is a highly nutritional fruit that is popularly consumed in Thailand. It has been used in traditional medicine due to its abundance of phytonutrients. The present study aimed to investigate the chemical compositions and antioxidant activity of Mahajanaka mango pulp extract (MPE) in vitro. Additionally, we examined its biological activities, including the analgesic, anti-inflammatory, gastroprotective, and hepatoprotective effects of MPE, in murine models. MPE exhibited high levels of phenolic compounds, mangiferin, β-carotene, and vitamin C, and it potentially showed antioxidant properties in an ABTS scavenging assay. The animal results have revealed that oral administration of MPE (1000 mg/kg body weight (BW)) significantly decreased acetic acid-induced writhing responses in mice. Interestingly, local applications of MPE at 1 mg/ear ameliorated ethyl phenylpropiolate (EPP)-induced ear edema, while gavage of MPE at 1000 mg/kg BW significantly decreased carrageenan-induced hind paw edema in rats. MPE can also protect against gastric ulcers induced by stress, hydrochloric acid/ethanol, and indomethacin in rats. Indeed, MPE (250 mg/kg BW) markedly lowered the level of serum alanine aminotransferase activity and hepatic lipid accumulation in rats with CCl<sub>4</sub>- and paracetamol-induced hepatotoxicity. Taken together, the findings suggested that MPE exerts potent antioxidant, analgesic, anti-inflammatory, gastroprotective, and hepatoprotective effects.https://www.mdpi.com/2076-3417/13/22/12216<i>Mangifera indica</i>Mahajanaka mangoantioxidantanalgesicanti-inflammatorygastroprotective |
| spellingShingle | Narisara Paradee Rattanaporn Janthip Tawat Taesothikul Duangta Kanjanapothi Kornvipa Settakorn Somdet Srichairatanakool Pimpisid Koonyosying Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models Applied Sciences <i>Mangifera indica</i> Mahajanaka mango antioxidant analgesic anti-inflammatory gastroprotective |
| title | Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models |
| title_full | Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models |
| title_fullStr | Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models |
| title_full_unstemmed | Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models |
| title_short | Antioxidant and Biological Activities of Mahajanaka Mango Pulp Extract in Murine Models |
| title_sort | antioxidant and biological activities of mahajanaka mango pulp extract in murine models |
| topic | <i>Mangifera indica</i> Mahajanaka mango antioxidant analgesic anti-inflammatory gastroprotective |
| url | https://www.mdpi.com/2076-3417/13/22/12216 |
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