A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia
Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the sec...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Cerebral Circulation - Cognition and Behavior |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666245023000338 |
| _version_ | 1797398983627243520 |
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| author | Sarmi Sri Adam Greenstein Alessandra Granata Alex Collcutt Angela C C Jochems Barry W McColl Blanca Díaz Castro Caleb Webber Carmen Arteaga Reyes Catherine Hall Catherine B Lawrence Cheryl Hawkes Chrysia-Maria Pegasiou-Davies Claire Gibson Colin L Crawford Colin Smith Denis Vivien Fiona H McLean Frances Wiseman Gaia Brezzo Giovanna Lalli Harry A T Pritchard Hugh S Markus Isabel Bravo-Ferrer Jade Taylor James Leiper Jason Berwick Jian Gan John Gallacher Jonathan Moss Jozien Goense Letitia McMullan Lorraine Work Lowri Evans Michael S Stringer MLJ Ashford Mohamed Abulfadl Nina Conlon Paresh Malhotra Philip Bath Rebecca Canter Rosalind Brown Selvi Ince Silvia Anderle Simon Young Sophie Quick Stefan Szymkowiak Steve Hill Stuart Allan Tao Wang Terry Quinn Tessa Procter Tracy D Farr Xiangjun Zhao Zhiyuan Yang Atticus H Hainsworth Joanna M Wardlaw |
| author_facet | Sarmi Sri Adam Greenstein Alessandra Granata Alex Collcutt Angela C C Jochems Barry W McColl Blanca Díaz Castro Caleb Webber Carmen Arteaga Reyes Catherine Hall Catherine B Lawrence Cheryl Hawkes Chrysia-Maria Pegasiou-Davies Claire Gibson Colin L Crawford Colin Smith Denis Vivien Fiona H McLean Frances Wiseman Gaia Brezzo Giovanna Lalli Harry A T Pritchard Hugh S Markus Isabel Bravo-Ferrer Jade Taylor James Leiper Jason Berwick Jian Gan John Gallacher Jonathan Moss Jozien Goense Letitia McMullan Lorraine Work Lowri Evans Michael S Stringer MLJ Ashford Mohamed Abulfadl Nina Conlon Paresh Malhotra Philip Bath Rebecca Canter Rosalind Brown Selvi Ince Silvia Anderle Simon Young Sophie Quick Stefan Szymkowiak Steve Hill Stuart Allan Tao Wang Terry Quinn Tessa Procter Tracy D Farr Xiangjun Zhao Zhiyuan Yang Atticus H Hainsworth Joanna M Wardlaw |
| author_sort | Sarmi Sri |
| collection | DOAJ |
| description | Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder. |
| first_indexed | 2024-03-09T01:33:24Z |
| format | Article |
| id | doaj.art-9ffe49ccbd5b476183d732a9dab4e59d |
| institution | Directory Open Access Journal |
| issn | 2666-2450 |
| language | English |
| last_indexed | 2024-03-09T01:33:24Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cerebral Circulation - Cognition and Behavior |
| spelling | doaj.art-9ffe49ccbd5b476183d732a9dab4e59d2023-12-09T06:08:05ZengElsevierCerebral Circulation - Cognition and Behavior2666-24502023-01-015100189A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementiaSarmi Sri0Adam Greenstein1Alessandra Granata2Alex Collcutt3Angela C C Jochems4Barry W McColl5Blanca Díaz Castro6Caleb Webber7Carmen Arteaga Reyes8Catherine Hall9Catherine B Lawrence10Cheryl Hawkes11Chrysia-Maria Pegasiou-Davies12Claire Gibson13Colin L Crawford14Colin Smith15Denis Vivien16Fiona H McLean17Frances Wiseman18Gaia Brezzo19Giovanna Lalli20Harry A T Pritchard21Hugh S Markus22Isabel Bravo-Ferrer23Jade Taylor24James Leiper25Jason Berwick26Jian Gan27John Gallacher28Jonathan Moss29Jozien Goense30Letitia McMullan31Lorraine Work32Lowri Evans33Michael S Stringer34MLJ Ashford35Mohamed Abulfadl36Nina Conlon37Paresh Malhotra38Philip Bath39Rebecca Canter40Rosalind Brown41Selvi Ince42Silvia Anderle43Simon Young44Sophie Quick45Stefan Szymkowiak46Steve Hill47Stuart Allan48Tao Wang49Terry Quinn50Tessa Procter51Tracy D Farr52Xiangjun Zhao53Zhiyuan Yang54Atticus H Hainsworth55Joanna M Wardlaw56UK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UKDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UKDepartment of Clinical Neurosciences, Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge CB2 0BB, UKUK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UKUK Dementia Research Institute Cardiff, Cardiff University, Cardiff CF24 4HQ, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UKSchool of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, East Sussex, UKGeoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKBiomedical and Life Sciences, Lancaster University, Lancaster, UKUK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UKSchool of Psychology, University of Nottingham, Nottingham NG7 2UH, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UKPhysiopathology and Imaging of Neurological Disorders (PhIND), Normandie University, UNICAEN, INSERM UMR-S U1237, , GIP Cyceron, Institute Blood and Brain @ Caen-Normandie (BB@C), Caen, France; Department of clinical research, Caen-Normandie University Hospital, Caen, FranceDivision of Systems Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UKUK Dementia Research Institute, University College London, London WC1N 3BG, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UKUK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UKDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UKStroke Research Group, Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UKDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UKBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UKDepartment of Psychology, University of Sheffield, Sheffield, UK; Neuroscience Institute, University of Sheffield, Sheffield, UK; Healthy Lifespan Institute, University of Sheffield, Sheffield, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UKDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK; The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UKNeuroscience Program, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Department of Psychology, University of Illinois, Urbana-Champaign, Champaign, IL, USA; Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL, USA; School of Psychology and Neuroscience, University of Glasgow, UKSchool of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, East Sussex, UKSchool of Cardiovascular & Metabolic Health, College of Medical, Veterinary & Life Sciences, University of Glasgow; Glasgow; UKDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UKDivision of Systems Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UKDementia Research Group, Department of Clinical Neurosciences, Bristol Medical School, University of Bristol, Bristol BS10 5NB, UKDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UKDepartment of Brain Sciences, Imperial College London, London, UK; Department of Neurology, Imperial College Healthcare NHS Trust, London, UK; UK Dementia Research Institute Care Research and Technology Centre, Imperial College London and the University of Surrey, UKStroke Trials Unit, University of Nottingham, Nottingham, UK; Stroke, Medicine Division, Nottingham University Hospitals NHS Trust, Nottingham, UKDementia Discovery Fund, SV Health Managers LLP, London, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UKDementia Research Group, Department of Clinical Neurosciences, Bristol Medical School, University of Bristol, Bristol BS10 5NB, UKSchool of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, East Sussex, UK; Department of Neuroscience, Physiology and Pharmacology, University College London, UKDementias Platform UK, Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UKCentre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute Cardiff, Cardiff University, Cardiff CF24 4HQ, UKCentre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute Cardiff, Cardiff University, Cardiff CF24 4HQ, UKGeoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKGeoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Division of Evolution, Infection and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, UK; Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester, UKCollege of Medical Veterinary and Life Sciences, University of Glasgow, Scotland, UKUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK; Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UKSchool of Life Sciences, Physiology, Pharmacology, and Neuroscience Division, Medical School, University of Nottingham, Nottingham NG7 2UH, UKDivision of Evolution, Infection and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, UKDepartment of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UKMolecular and Clinical Sciences Research Institute, St George's University of London SW17 0RE, UK; Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UKCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK; Corresponding author at: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.http://www.sciencedirect.com/science/article/pii/S2666245023000338Vascular cognitive impairmentVascular dementiaSmall vessel diseaseCerebral vascular diseaseDementia |
| spellingShingle | Sarmi Sri Adam Greenstein Alessandra Granata Alex Collcutt Angela C C Jochems Barry W McColl Blanca Díaz Castro Caleb Webber Carmen Arteaga Reyes Catherine Hall Catherine B Lawrence Cheryl Hawkes Chrysia-Maria Pegasiou-Davies Claire Gibson Colin L Crawford Colin Smith Denis Vivien Fiona H McLean Frances Wiseman Gaia Brezzo Giovanna Lalli Harry A T Pritchard Hugh S Markus Isabel Bravo-Ferrer Jade Taylor James Leiper Jason Berwick Jian Gan John Gallacher Jonathan Moss Jozien Goense Letitia McMullan Lorraine Work Lowri Evans Michael S Stringer MLJ Ashford Mohamed Abulfadl Nina Conlon Paresh Malhotra Philip Bath Rebecca Canter Rosalind Brown Selvi Ince Silvia Anderle Simon Young Sophie Quick Stefan Szymkowiak Steve Hill Stuart Allan Tao Wang Terry Quinn Tessa Procter Tracy D Farr Xiangjun Zhao Zhiyuan Yang Atticus H Hainsworth Joanna M Wardlaw A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia Cerebral Circulation - Cognition and Behavior Vascular cognitive impairment Vascular dementia Small vessel disease Cerebral vascular disease Dementia |
| title | A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia |
| title_full | A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia |
| title_fullStr | A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia |
| title_full_unstemmed | A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia |
| title_short | A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia |
| title_sort | multi disciplinary commentary on preclinical research to investigate vascular contributions to dementia |
| topic | Vascular cognitive impairment Vascular dementia Small vessel disease Cerebral vascular disease Dementia |
| url | http://www.sciencedirect.com/science/article/pii/S2666245023000338 |
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