Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation
Abstract Objective This study aims to examine the relationship between antenatal magnesium sulfate (MgSO4) and neonatal death and/or severe necrotizing enterocolitis (NEC) among infants < 28 weeks. Methods Secondary analysis of a multicenter randomized trial of antenatal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2016-03-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1581059 |
| _version_ | 1818926888190476288 |
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| author | Manijeh Kamyar Erin A. S. Clark Bradley A. Yoder Michael W. Varner Tracy A. Manuck |
| author_facet | Manijeh Kamyar Erin A. S. Clark Bradley A. Yoder Michael W. Varner Tracy A. Manuck |
| author_sort | Manijeh Kamyar |
| collection | DOAJ |
| description | Abstract
Objective This study aims to examine the relationship between antenatal magnesium sulfate (MgSO4) and neonatal death and/or severe necrotizing enterocolitis (NEC) among infants < 28 weeks.
Methods Secondary analysis of a multicenter randomized trial of antenatal MgSO4 versus placebo administered to women to prevent death and cerebral palsy. Neonates < 28 weeks were included. The primary outcome was neonatal death before NICU discharge, and/or severe NEC (Bell criteria stage II/III). Neonates with and without death/severe NEC were compared.
Results A total of 697 neonates met the criteria. Out of which 150 (21.5%) died and/or were diagnosed with severe NEC. Antenatal MgSO4 exposure was not associated with death/severe NEC in infants < 28 weeks. In a subgroup analysis of neonates < 26 weeks, treatment group assignment to antenatal MgSO4 was associated with an increased odds of death/severe NEC (adjusted odds ratio: 1.90, 95% confidence interval: 1.12–3.22, p = 0.017).
Conclusions Among neonates < 26 weeks, antenatal MgSO4 was associated with death and severe NEC. Further prospective study in larger populations is needed. |
| first_indexed | 2024-12-20T03:04:16Z |
| format | Article |
| id | doaj.art-a000dc9eff744d9fa07cde37e597a83f |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-20T03:04:16Z |
| publishDate | 2016-03-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-a000dc9eff744d9fa07cde37e597a83f2022-12-21T19:55:39ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052016-03-010601e148e15410.1055/s-0036-1581059Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks GestationManijeh Kamyar0Erin A. S. Clark1Bradley A. Yoder2Michael W. Varner3Tracy A. Manuck4Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UtahDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UtahDivision of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UtahDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UtahDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UtahAbstract Objective This study aims to examine the relationship between antenatal magnesium sulfate (MgSO4) and neonatal death and/or severe necrotizing enterocolitis (NEC) among infants < 28 weeks. Methods Secondary analysis of a multicenter randomized trial of antenatal MgSO4 versus placebo administered to women to prevent death and cerebral palsy. Neonates < 28 weeks were included. The primary outcome was neonatal death before NICU discharge, and/or severe NEC (Bell criteria stage II/III). Neonates with and without death/severe NEC were compared. Results A total of 697 neonates met the criteria. Out of which 150 (21.5%) died and/or were diagnosed with severe NEC. Antenatal MgSO4 exposure was not associated with death/severe NEC in infants < 28 weeks. In a subgroup analysis of neonates < 26 weeks, treatment group assignment to antenatal MgSO4 was associated with an increased odds of death/severe NEC (adjusted odds ratio: 1.90, 95% confidence interval: 1.12–3.22, p = 0.017). Conclusions Among neonates < 26 weeks, antenatal MgSO4 was associated with death and severe NEC. Further prospective study in larger populations is needed.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1581059magnesium sulfatepreterm deliverynecrotizing enterocolitis |
| spellingShingle | Manijeh Kamyar Erin A. S. Clark Bradley A. Yoder Michael W. Varner Tracy A. Manuck Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation American Journal of Perinatology Reports magnesium sulfate preterm delivery necrotizing enterocolitis |
| title | Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation |
| title_full | Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation |
| title_fullStr | Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation |
| title_full_unstemmed | Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation |
| title_short | Antenatal Magnesium Sulfate, Necrotizing Enterocolitis, and Death among Neonates < 28 Weeks Gestation |
| title_sort | antenatal magnesium sulfate necrotizing enterocolitis and death among neonates 28 weeks gestation |
| topic | magnesium sulfate preterm delivery necrotizing enterocolitis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1581059 |
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