Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone Fractures
Background and purpose: Non::union:: of bone fracture is a clinical and treatment challenge. Satisfactory repair of orthopedic fractures is of great importance and systemic treatment is used to achieve this goal. This study aimed to investigate the effect of Teriparatide (CinnoPar®) on non::union::...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2019-06-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-8633-en.html |
| _version_ | 1797943871682904064 |
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| author | Masoud Shayestehazar Mohammad hossein Kariminasab Ghasem Janbabaei Salman Ghafari Mehran Razavipour Sara Mahdavi Abolfazle Kazemi Iman Sadeghian |
| author_facet | Masoud Shayestehazar Mohammad hossein Kariminasab Ghasem Janbabaei Salman Ghafari Mehran Razavipour Sara Mahdavi Abolfazle Kazemi Iman Sadeghian |
| author_sort | Masoud Shayestehazar |
| collection | DOAJ |
| description | Background and purpose: Non::union:: of bone fracture is a clinical and treatment challenge. Satisfactory repair of orthopedic fractures is of great importance and systemic treatment is used to achieve this goal. This study aimed to investigate the effect of Teriparatide (CinnoPar®) on non::union:: fractures.
Materials and methods: A quasi-experimental study was conducted in 17 patients with non::union:: bone fractures. Radiographic evaluation was performed before the intervention and non::union:: was confirmed by a radiologist. Then, all patients received Teriparatide for three months. Afterwards, a control x-ray image was taken to assess the outcome.
Results: Sixteen patients (mean age: 45.18±20.51) with non::union:: fracture were evaluated, including nine males and seven females. The mean time after the accident was 50 ±24.48 weeks. Femoral bone was the most reported impaired site (n=8). After treatment with Teriparatide (CinnoPar®) improvements were seen in 10 patients (P= 0.002).
Conclusion: Treatment with CinnoPar® was found to be effective to some extent. However, due to the small sample size in this study, the efficacy of CinnoPar® needs further assessments. |
| first_indexed | 2024-04-10T20:30:57Z |
| format | Article |
| id | doaj.art-a0024f9f0f894662a229920cd0578271 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:30:57Z |
| publishDate | 2019-06-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-a0024f9f0f894662a229920cd05782712023-01-25T06:56:44ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792019-06-01291737582Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone FracturesMasoud Shayestehazar0Mohammad hossein Kariminasab1Ghasem Janbabaei2Salman Ghafari3Mehran Razavipour4Sara Mahdavi5Abolfazle Kazemi6Iman Sadeghian7 Associate Professor, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Department of Hematology and Oncology, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran Assistant professor of orthopedic surgery, Orthopedic research center, Mazandaran University of Medical Science, Sari, Iran Medical Student, Student research committee, Mazandaran University of medical sciences, Sari, Iran Resident in Orthopedic Surgery, Orthopedic Research center, Mazandaran University of Medical Sciences, Sari, Iran Resident in Orthopedic Surgery, Orthopedic Research center, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Non::union:: of bone fracture is a clinical and treatment challenge. Satisfactory repair of orthopedic fractures is of great importance and systemic treatment is used to achieve this goal. This study aimed to investigate the effect of Teriparatide (CinnoPar®) on non::union:: fractures. Materials and methods: A quasi-experimental study was conducted in 17 patients with non::union:: bone fractures. Radiographic evaluation was performed before the intervention and non::union:: was confirmed by a radiologist. Then, all patients received Teriparatide for three months. Afterwards, a control x-ray image was taken to assess the outcome. Results: Sixteen patients (mean age: 45.18±20.51) with non::union:: fracture were evaluated, including nine males and seven females. The mean time after the accident was 50 ±24.48 weeks. Femoral bone was the most reported impaired site (n=8). After treatment with Teriparatide (CinnoPar®) improvements were seen in 10 patients (P= 0.002). Conclusion: Treatment with CinnoPar® was found to be effective to some extent. However, due to the small sample size in this study, the efficacy of CinnoPar® needs further assessments.http://jmums.mazums.ac.ir/article-1-8633-en.htmlcinnopar®non::union::bone fractureteriparatide |
| spellingShingle | Masoud Shayestehazar Mohammad hossein Kariminasab Ghasem Janbabaei Salman Ghafari Mehran Razavipour Sara Mahdavi Abolfazle Kazemi Iman Sadeghian Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone Fractures Journal of Mazandaran University of Medical Sciences cinnopar® non::union:: bone fracture teriparatide |
| title | Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone Fractures |
| title_full | Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone Fractures |
| title_fullStr | Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone Fractures |
| title_full_unstemmed | Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone Fractures |
| title_short | Effect of Teriparatide (CinnoPar®) in Treatment of Non::union:: Bone Fractures |
| title_sort | effect of teriparatide cinnopar r in treatment of non union bone fractures |
| topic | cinnopar® non::union:: bone fracture teriparatide |
| url | http://jmums.mazums.ac.ir/article-1-8633-en.html |
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